CYTOKINES IN HUMAN-MELANOMA CELLS - SYNTHESIS, AUTOCRINE STIMULATION AND REGULATORY FUNCTIONS - AN OVERVIEW

被引：37
作者：
KRASAGAKIS, K
GARBE, C
ORFANOS, CE
机构：
[1] University Medical Center Steglitz, University of Berlin
来源：
MELANOMA RESEARCH | 1993年 / 3卷 / 06期
关键词：
CYTOKINES; GROWTH FACTORS; LYMPHOKINES; MELANOMA CELLS;
D O I：
10.1097/00008390-199311000-00005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Various cytokines are involved in growth regulation of human melanoma cells. Malignant melanoma cells express multiple growth factors, including basic fibroblast growth factor (bFGF), transforming growth factor (TGF)-alpha, platelet-derived growth factor (PDGF)-alpha, and melanoma growth stimulatory activity (MGSA), substances which are not expressed In normal human melanocytes. The simultaneous synthesis of growth factors and expression of their receptors by melanoma cells, leading to permanent stimulation of cell proliferation, has been clearly shown for bFGF and MGSA. This phenomenon has been designated autocrine growth stimulation. Increased or altered expression of growth factor receptors has been described for nerve growth factor (NGF) receptor, for PDGF-beta receptor and for a truncated form of epidermal growth factor (EGF) receptor encoded by the c-erb-B2 oncogene. Lymphokines are mainly involved in growth control of melanoma cells. Interferons (IFN)-alpha, -beta and -gamma, interleukins (IL)-1 and -6 as well as tumour necrosis factor (TNF)-alpha inhibited melanoma cell proliferation, with the strongest effects displayed by IFN. TGF-beta which was found to inhibit proliferation of normal human melanocytes exhibited marginal effects on melanoma cells, or even stimulated their growth. In conclusion, a complex network of cytokines is Involved In the regulation of melanoma cell growth. Further insight into these mechanisms may contribute to the finding of new strategies in melanoma therapy.
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页码：425 / 433
页数：9
相关论文
共 107 条
[1]  
Sporn M.B., Roberts A.B., Peptide growth factors are multifunctional, Nature, 332, pp. 217-219, (1988)
[2]  
Balkwill F.R., Burke F., The cytokine network, Immunol Today, 10, pp. 299-305, (1989)
[3]  
Rothe M., Factors F.V., Their biology and promise in dermatologic diseases and tissue repair, Arch Dermatol, 125, pp. 1390-1398, (1989)
[4]  
Ibelgaufts H., Lexikon Zytokine, (1992)
[5]  
Goustin A.S., Leof E.B., Shipley G.D., Growth factors and cancer, Cancer Res, 46, pp. 1015-1029, (1986)
[6]  
Todaro G.J., Delarco J.E., Growth factors produced by sarcoma virus-transformed cells, Cancer Res, 38, pp. 4147-4154, (1978)
[7]  
Sporn M.B., Roberts A.B., Autocrine growth factors and cancer, Nature, 313, pp. 745-747, (1985)
[8]  
Eisinger M., Marco O. Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin. Proc Natl Acad Sci, USA, 79, pp. 2018-2022, (1982)
[9]  
Gilchrest B.A., Vrabel M.A., Flynn E., Selective cultivation of human melanocytes from newborn and adult epidermis, J Invest Dermatol, 83, pp. 370-376, (1984)
[10]  
Halaban R., Ghosh S., Baird A., BFGF is the putative natural growth factor for human melanocytes, In Vitro, 23, pp. 47-52, (1987)
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