PRODUCTION OF HUMAN ALPHA-INTERFERON AND GAMMA-INTERFERON IS DEPENDENT ON AGE AND SEX AND IS DECREASED IN RHEUMATOID-ARTHRITIS - A SIMPLE METHOD FOR A LARGE-SCALE ASSAY

被引：20
|
作者：
KITA, M
SHIOZAWA, S
YAMAJI, M
KITOH, I
KISHIDA, T
机构：
[1] KOBE UNIV,SCH MED,DEPT MED,DIV 3,7-5 KUSUNOKICHO,CHUO KU,KOBE 650,JAPAN
[2] INST PASTEUR KYOTO,DEPT VIROL,KYOTO,JAPAN
来源：
JOURNAL OF CLINICAL LABORATORY ANALYSIS | 1991年 / 5卷 / 04期
关键词：
IFN; SENDAI VIRUS; CONCANAVALIN-A;
D O I：
10.1002/jcla.1860050403
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
We examined host ability to produce alpha- and gamma-interferon on a large scale by culturing 2 ml of peripheral blood for 20 hr with Sendai virus or concanavalin A as inducer of alpha- or gamma-interferon, respectively. Production of gamma- but not alpha-interferon was lower in females (n = 351) than in males (n = 531) (P < 0.001). Both alpha- and gamma-interferon production declined gradually with ageing. The production of alpha-interferon (3,233 +/- 1,773 IU/ml) and gamma-interferon 19 +/- 20 IU/ml) in rheumatoid arthritis patients was significantly lower than the values found in total and age-matched healthy donors (P < 0.01). These results suggest that interferon production is dependent on age and sex and is significantly lower in patients with rheumatoid arthritis.
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页码：238 / 241
页数：4
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