THE ROLE OF LIPID-PEROXIDATION PRODUCTS IN CUMENE HYDROPEROXIDE-INDUCED CA2+ EFFLUX FROM MITOCHONDRIA

被引：9
作者：
GOGVADZE, VG
ZHUKOVA, AA
机构：
[1] Institute of Theoretical and Experimental Biophysics, USSR Academy of Sciences, Pushchino
来源：
FEBS LETTERS | 1991年 / 287卷 / 1-2期
关键词：
MITOCHONDRIA; LIPID PEROXIDATION; CALCIUM; CUMENE HYDROPEROXIDE;
D O I：
10.1016/0014-5793(91)80034-Z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cumene hydroperoxide-induced calcium release from mitochondria has been studied. Activation of lipid peroxidation by increasing concentrations of cumene hydroperoxide does not enhance calcium efflux induced by low (up to 50-mu-M) concentration of cumene hydroperoxide. It is concluded that cumene hydroperoxide-induced calcium release depends mainly on processes coupled to hydroperoxide reduction by an endogenous enzyme system.
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页码：139 / 141
页数：3
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