STRAIN DIFFERENCES IN RAT-LIVER UDP-GLUCURONYLTRANSFERASE ACTIVITY TOWARDS ANDROSTERONE

被引：39
作者：
MATSUI, M
NAGAI, F
AOYAGI, S
机构：
来源：
BIOCHEMICAL JOURNAL | 1979年 / 179卷 / 03期
关键词：
D O I：
10.1042/bj1790483
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Male Donryu, Wistar and Wistar King rats showed discontinuous variations in hepatic microsomal UDP-glucuronyltransferase activities towards androsterone, but not towards testosterone, bilirubin, phenolphthalein and 4-nitrophenol. Fresh microsomal fraction with a low transferase activity towards androsterone formed 0.049-0.080 nmol of glucuronide/min per mg of protein, whereas fresh microsomal fraction with a high transferase activity towards androsterone formed 0.335-0.557 nmol of glucuronide/min per mg of protein. The microsomal fraction with low enzyme activity towards androsterone was not stimulated by treatment with Triton X-100 or freezing and thawing. In contrast, male Long Evans and Sprague-Dawley rats did not exhibit such diversity.
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页码：483 / 487
页数：5
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