EFFECTS OF ARABINOSYL-CYTOSINE ON THYMIDINE TRIPHOSPHATE POOLS AND POLYOMA DNA-REPLICATION

被引：35
作者：
HELLGREN, D
NILSSON, S
REICHARD, P
机构：
[1] Medical Nobel Institute, Department of Biochemistry, Karolinska Institute
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 01期
关键词：
D O I：
10.1016/0006-291X(79)91690-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Arabinosyl cytosine at very low concentrations (5-100 nmolar) inhibits the incorporation of [3H]thymidine into polyoma DNA of infected mouse fibroblasts without affecting the labeling of the [3H]dTTP pool. The specific activities of these pools were determined by a new simple method. Inhibition of DNA synthesis affects chain elongation and not initiation of new rounds of replication. © 1979.
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页码：16 / 22
页数：7
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