MECHANISM OF BRONCHODILATOR EFFECT IN CHRONIC AIR-FLOW LIMITATION

被引:0
作者
JAESCHKE, R
GUYATT, GH
SINGER, J
KELLER, J
NEWHOUSE, MT
机构
[1] MCMASTER UNIV,HLTH SCI CTR,DEPT CLIN EPIDEMIOL & BIOSTAT,RM 2C12,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA
[2] ST JOSEPHS HOSP,FIRESTONE CHEST & ALLERGY UNIT,HAMILTON L8N 1Y4,ONTARIO,CANADA
[3] MCMASTER UNIV,DEPT MED,HAMILTON L8N 3Z5,ONTARIO,CANADA
[4] MCMASTER UNIV,DEPT FAMILY MED,HAMILTON L8N 3Z5,ONTARIO,CANADA
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D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To examine the mechamisms through which two bronchodilators (theophylline and salbutamol) influence dyspnea during daily activities. Methods: Twenty-four patients with chronic airflow limitation participated in a multiple crossover, randomized, placebo-controlled trial. The effect of theophylline and salbutamol, alone or combined, on pulmonary function and dyspnea during daily activities was examined. Correlations of changes in forced expiratory volume in 1 second (FEV1) and maximum expiratory pressures (MIPs) (independent variables) and changes in dyspnea score during daily activities (dependent variable) were also examined. Results: The two drugs proved to be beneficial: the effects in general were additive rather than synergistic. The drugs improved the FEV1; theophylline significantly improved the MIPs. The correlation between the changes in FEV1 and those in dyspnea score, after adjustment for the changes in MIPs, was 0.55 (p < 0.001). The correlation between the changes in MIPs and those in dyspnea score, after adjustment for the changes in FEV1, was 0.39 (p < 0.001). Conclusions: Changes in airway calibre and in respiratory muscle strength play an independent and important role in dyspnea during daily activities in patients with chronic airflow limitation. Changes in airway calibre may be of greater importance.
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页码:35 / 39
页数:5
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