Comparison of abdominal bloating severity between irritable bowel syndrome patients with high and low levels of breath hydrogen excretion in a lactulose breath test

被引：4
作者：
Lasa, J. [1 ]
Peralta, D. [1 ]
Dima, G. [1 ]
Novillo, A. [1 ]
Besasso, H. [1 ]
Soifer, L. [1 ]
机构：
[1] CEMIC, Div Gastroenterol, Internal Med Dept, Buenos Aires, DF, Argentina
来源：
REVISTA DE GASTROENTEROLOGIA DE MEXICO | 2012年 / 77卷 / 02期
关键词：
Irritable bowel syndrome; Breath test; Bacterial overgrowth; Intestinal dysmotility; Argentina;
D O I：
10.1016/j.rgmx.2012.02.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background: There is growing evidence that gut flora plays a role in the development of Irri- table Bowel Syndrome (IBS). Abdominal bloating is a common symptom in these patients and the severity of this symptom could be related to the variations in their fermentative profiles, obtained by measuring the levels of breath hydrogen excretion after lactulose ingestion. Aims: Our objective was to determine the difference in abdominal bloating severity between IBS patients with high vs low levels of breath hydrogen excretion after lactulose administration. Methods: Lactutose breath tests were carried out on IBS patients in our institution between July 2009 and August 2010. Patients were requested to fill out a validated questionnaire to assess the severity of their symptoms. Abdominal bloating severity score was compared among patients with high and low breath hydrogen levels. Results: A total of 234 patients were enrolled. There was a statistically significant difference in the abdominal bloating severity score between groups: 7.0 (5.7-8.0) vs 6.5 (5.0-7.5), p=0.001. The comparison among IBS patients with constipation (IBS-C) in both groups also showed a statistically significant difference: 7.5 (6.0-8.5) vs 5.8 (3.5-7.2), p=0.0051. Conclusions: Those patients with a low level of breath hydrogen excretion after Lactutose ingestion presented with significantly greater abdominal bloating than those with a high level of breath hydrogen excretion. (C) 2011 Asociacion Mexicana de Gastroenterologia. Published by Masson Doyma Mexico S.A. All rights reserved.
引用
收藏
页码：53 / 57
页数：5
相关论文
共 25 条
[11]  
Koide A, 2000, AM J GASTROENTEROL, V95, P1735
[12]  
KOTLER DP, 1982, J LAB CLIN MED, V100, P798
[13]   Functional bowel disorders [J].
Longstreth, George F. ;
Thompson, W. Grant ;
Chey, William D. ;
Houghton, Lesley A. ;
Mearin, Fermin ;
Spiller, Robin C. .
GASTROENTEROLOGY, 2006, 130 (05) :1480-1491
[14]   ABDOMINAL DISTENSION IN FEMALE-PATIENTS WITH IRRITABLE-BOWEL-SYNDROME - EXPLORATION OF POSSIBLE MECHANISMS [J].
MAXTON, DG ;
MARTIN, DF ;
WHORWELL, PJ ;
GODFREY, M .
GUT, 1991, 32 (06) :662-664
[15]   Irritable bowel syndrome [J].
Mayer, Emeran A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (16) :1692-1699
[16]   IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen [J].
Pimentel, M ;
Kong, YT ;
Park, S .
DIGESTIVE DISEASES AND SCIENCES, 2004, 49 (01) :84-87
[17]   Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: A double-blind, randomized, placebo-controlled study [J].
Pimentel, M ;
Chow, EJ ;
Lin, HC .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2003, 98 (02) :412-419
[18]  
Pimentel M, 2000, AM J GASTROENTEROL, V95, P3503, DOI 10.1111/j.1572-0241.2000.03368.x
[19]   The effect of a nonabsorbed oral antibiotic (Rifaximin) on the symptoms of the irritable bowel syndrome - A randomized trial [J].
Pimentel, Mark ;
Park, Sandy ;
Mirocha, James ;
Kane, Sunanda V. ;
Kong, Yuthana .
ANNALS OF INTERNAL MEDICINE, 2006, 145 (08) :557-563
[20]   Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: Subanalysis of a double-blind randomized controlled study [J].
Pimentel, Mark ;
Chatterjee, Soumya ;
Chow, Evelyn J. ;
Park, Sandy ;
Kong, Yuthana .
DIGESTIVE DISEASES AND SCIENCES, 2006, 51 (08) :1297-1301
123