LIPOGENESIS INSITU IN GENETICALLY OBESE ZUCKER FATTY RAT (FA-FA) - ROLE OF HYPERPHAGIA AND HYPERINSULINEMIA

被引：114

作者：

GODBOLE, V ^{[1
]}

YORK, DA ^{[1
]}

机构：

[1] SOUTHAMPTON UNIV,SCH BIOCHEM & PHYSIOL SCI,DEPT NUTR,SOUTHAMPTON S09 3TU,ENGLAND

来源：

DIABETOLOGIA | 1978年 / 14卷 / 03期

关键词：

adipose tissue; insulin; lipogenesis; Liver; pair-feeding; streptozotocin; Zucker fatty rat;

D O I：

10.1007/BF00429780

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In situ fatty acid synthesis has been measured with 3H2O in anaesthetised lean and obese Zucker (fa/fa) rats. The accumulation of fatty acids was increased in both the liver and adipose tissue of young fa/fa rats as a result of both an increased rate of lipogenesis and an increase in tissue mass. Whereas total hepatic lipogenesis increased with age, total adipose tissue lipogenesis decreased in older fa/fa rats. Experiments with hepatectomized rats showed that the liver was the major site of the excess fatty acid synthesis in fa/fa rats. The enhanced rate of lipogenesis in fa/fa rats was abolished by either pairfeeding or streptozotocin treatment. The results suggest that the increased fatty acid synthesis in fa/fa rats is secondary to the hyperphagia, hpyerinsulinaemia, and increased mass of hepatic and adipose tissues. © 1978 Springer-Verlag.

引用

页码：191 / 197

页数：7

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