ACETOGENIC ISOQUINOLINE ALKALOIDS .66. FIRST TOTAL SYNTHESIS OF KORUPENSAMINE-A AND KORUPENSAMINE-B

被引：45

作者：

BRINGMANN, G

GOTZ, R

KELLER, PA

WALTER, R

HENSCHEL, P

SCHAFFER, M

STABLEIN, M

KELLY, TR

BOYD, MR

机构：

[1] BOSTON COLL,DEPT CHEM,CHESTNUT HILL,MA 02167

[2] NCI,DRUG DISCOVERY RES & DEV LAB,FREDERICK,MD 21702

来源：

HETEROCYCLES | 1994年 / 39卷 / 02期

关键词：

D O I：

10.3987/COM-94-S(B)79

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of korupensamines A (1a) and B (1b), highly polar naphthylisoquinoline alkaloids and, simultaneously, 'monomeric building blocks' of the michellamines, is described. Key step is the Pd-II catalyzed intermolecular biaryl coupling of the two appropriately protected naphthalene and isoquinoline moieties (10) and (11), with the coupling positions activated by bromine and trialkylstannane substituents respectively.

引用

页码：503 / 508

页数：6

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