CHRONIC METHANESULFONYL FLUORIDE ENHANCES ONE-TRIAL PER DAY REWARD LEARNING IN AGED RATS

被引：14

作者：

MALIN, DH ^{[1
]}

PLOTNER, RE ^{[1
]}

RADULESCU, SJ ^{[1
]}

FEREBEE, RN ^{[1
]}

LAKE, JR ^{[1
]}

NEGRETE, PG ^{[1
]}

SCHAEFER, PJ ^{[1
]}

CROTHERS, MK ^{[1
]}

MOSS, DE ^{[1
]}

机构：

[1] UNIV TEXAS, DEPT PSYCHOL, EL PASO, TX 79968 USA

来源：

NEUROBIOLOGY OF AGING | 1993年 / 14卷 / 04期

关键词：

METHANESULFONYL FLUORIDE; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; REWARD LEARNING; AGING; ONE-TRIAL LEARNING; MEMORY; ASPARTATE TRANSAMINASE;

D O I：

10.1016/0197-4580(93)90127-W

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly greater speed and accuracy on a 1 trial/day discriminative reward learning task. The chronic MSF treatment resulted in a 56% decrease in brain AChE activity but no discernable locomotor side effects and no liver damage as indicated by aspartate transferase activity.

引用

页码：393 / 395

页数：3

共 16 条

[1]

AMES DJ, 1988, LANCET, V1, P887

[2]

CHURCHILL L, 1984, J NEUROSCI, V4, P2069

[3]

DAVIES P, 1981, STRATEGIES DEV EFFEC, P19

[4]

ELLIS G, 1978, AM J CLIN PATHOL, V70, P248