SURGICAL-MANAGEMENT OF MALIGNANT OVARIAN GERM-CELL TUMORS - 10 YEARS EXPERIENCE OF 129 PATIENTS

被引:75
作者
PECCATORI, F [1 ]
BONAZZI, C [1 ]
CHIARI, S [1 ]
LANDONI, F [1 ]
COLOMBO, N [1 ]
MANGIONI, C [1 ]
机构
[1] UNIV MILAN,IST SCI BIOMED SAN GERARDO,DEPT OBSTET & GYNECOL,MONZA,ITALY
关键词
D O I
10.1016/0029-7844(95)00192-T
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To evaluate the surgical management of ovarian germ-cell tumors treated at a single institution during the last decade. Methods: One hundred twenty-nine patients affected by ovarian germ-cell tumors were studied retrospectively for their surgical management. Fifty-seven patients were affected by dysgerminoma, 39 by non-dysgerminoma, and 33 by pure immature teratoma. Seventy-nine patients were stage I according to International Federation of Gynecology and Obstetrics criteria, with five first referred at recurrence, 11 at stage II, 35 at stage III, and four at stage IV. Results: Fertility-sparing surgery was performed in 108 of 129 patients. Eighty-five of 100 referred patients underwent surgical or radiologic restaging, with an increase in staging in 16 cases. Three patients with immature teratoma underwent second laparotomy for a growing mass. Thirty-one patients underwent second-look surgery, with positive findings in four cases. Three patients did not respond to chemotherapy, and ten had a recurrence after complete response or surveillance. Six patients died of tumor, with an overall survival of 96% (mean follow-up time 55 months). Conclusion: Fertility-sparing surgery is warranted in all ovarian germ-cell tumors because it does not affect recurrence rate or survival. Extensive tumor-reductive surgery is advisable only in immature teratoma patients and is not necessary for other histologic types. Restaging can bg useful in selected cases, but the administration of effective chemotherapy, when needed, seems to be more important. The usefulness of second-look surgery is marginal.
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页码:367 / 372
页数:6
相关论文
共 36 条
[1]  
BONAZZI C, 1994, OBSTET GYNECOL, V84, P598
[2]  
CHAMBERS SK, 1988, OBSTET GYNECOL, V72, P404
[3]  
CREASMAN WT, 1979, OBSTET GYNECOL, V53, P226
[4]   ASSESSMENT OF THE CONTEMPORARY MANAGEMENT OF GERM-CELL MALIGNANCIES OF THE OVARY [J].
CREASMAN, WT ;
SOPER, JT .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1985, 153 (08) :828-834
[5]   MALIGNANT GERM-CELL TUMORS OF THE OVARY - 20-YEAR REPORT OF LAC-USC WOMENS HOSPITAL [J].
CURTIN, JP ;
MORROW, CP ;
DABLAING, G ;
SCHLAERTH, JB .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 1994, 4 (01) :29-35
[6]   NATURAL-HISTORY OF DYSGERMINOMA [J].
DEPALO, G ;
PILOTTI, S ;
KENDA, R ;
RATTI, E ;
MUSUMECI, R ;
MANGIONI, C ;
DIRE, F ;
LATTUADA, A ;
CONTI, U ;
CEFIS, F ;
RECANATINI, L ;
CARINELLI, S ;
ROSSI, G .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1982, 143 (07) :799-807
[7]   NONDYSGERMINOMATOUS TUMORS OF THE OVARY TREATED WITH CISPLATIN, VINBLASTINE, AND BLEOMYCIN - LONG-TERM RESULTS [J].
DEPALO, G ;
ZAMBETTI, M ;
PILOTTI, S ;
ROTTOLI, L ;
SPATTI, G ;
FONTANELLI, R ;
MUSUMECI, R ;
KENDA, R ;
BOMBARDIERI, E ;
STEFANON, B ;
ESCOBEDO, A ;
DELVECCHIO, M ;
DIDONATO, P ;
DIRE, F .
GYNECOLOGIC ONCOLOGY, 1992, 47 (02) :239-246
[8]   MALIGNANT OVARIAN GERM-CELL TUMORS - THE EXPERIENCE AT THE HOSPITAL-DE-LA-SANTA-CREU-I-SANT-PAU [J].
GERMA, JR ;
IZQUIERDO, MA ;
SEGUI, MA ;
CLIMENT, MA ;
OJEDA, B ;
ALONSO, C .
GYNECOLOGIC ONCOLOGY, 1992, 45 (02) :153-159
[9]   TREATMENT OF MALIGNANT GERM-CELL TUMORS OF THE OVARY WITH BLEOMYCIN, ETOPOSIDE, AND CISPLATIN [J].
GERSHENSON, DM ;
MORRIS, M ;
CANGIR, A ;
KAVANAGH, JJ ;
STRINGER, CA ;
EDWARDS, CL ;
SILVA, EG ;
WHARTON, JT .
JOURNAL OF CLINICAL ONCOLOGY, 1990, 8 (04) :715-720
[10]   UPDATE ON MALIGNANT OVARIAN GERM-CELL TUMORS [J].
GERSHENSON, DM .
CANCER, 1993, 71 (04) :1581-1590