IN-VITRO ANTIPLASMODIAL ACTIVITY AND CHLOROQUINE-POTENTIATING ACTION OF 3 NEW ISOQUINOLINE ALKALOID DIMERS ISOLATED FROM HERNANDIA-VOYRONII JUMELLE

被引：17

作者：

RATSIMAMANGAURVERG, S

RASOANAIVO, P

RAFATRO, H

ROBIJAONA, B

RAKOTORATSIMAMANGA, A

机构：

[1] Inst Malgache Recherches Appliquees, 101 Antananarivo

来源：

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY | 1994年 / 88卷 / 03期

关键词：

D O I：

10.1080/00034983.1994.11812867

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Three new isoquinoline alkaloid dimers with pavine and benzyl-tetrahydroisoquinoline moieties have been isolated, by bioassay-guided fractionation, from an alkaloid extract of Hernandia (= Hazomalania) voyronii Jumelle. All had inherent antiplasmodial activity in vitro and two enhanced chloroquine effectiveness in vitro in a dose-dependent manner. Some structure requirements for the chloroquine-potentiating action were identified in the isoquinoline series. These results, if confirmed in vivo, would account for the traditional use of H. voyronii as an adjuvant to complement chloroquine action in Malagasy herbal remedies.

引用

页码：271 / 277

页数：7

共 20 条

[1]

ANDRIANTSOA JR, 1988, B ACADEMIE MALGACHE, V66, P103

[2]

FOJO A, 1985, CANCER RES, V45, P3002

[3] REAPPEARANCE OF ANOPHELES-FUNESTUS AS A MALARIA VECTOR IN THE ANTANANARIVO REGION, MADAGASCAR [J].