METAL-IONS CATALYTIC FOR FREE-RADICAL REACTIONS IN THE PLASMA OF PATIENTS WITH FULMINANT HEPATIC-FAILURE

被引：21

作者：

EVANS, PJ

EVANS, RW

BOMFORD, A

WILLIAMS, R

HALLIWELL, B

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DIV BIOCHEM & MOLEC BIOL,LONDON SE1 9RT,ENGLAND

[2] KINGS COLL,INST LIVER STUDIES,LONDON SE5 9PJ,ENGLAND

来源：

FREE RADICAL RESEARCH | 1994年 / 20卷 / 03期

基金：

英国医学研究理事会;

关键词：

FULMINANT HEPATIC FAILURE; IRON; COPPER; BLEOMYCIN; LIVER; FREE RADICALS;

D O I：

10.3109/10715769409147511

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We propose that the frequency and severity of multi-organ failure (MOF) in fulminant hepatic failure (FHF) involves free radical damage caused by the presence of circulating iron and copper ions, catalytic for free radical reactions. The presence of such metal ions is demonstrated by using the sensitive bleomycin and phenanthroline assays. Antioxidant therapy, e.g., using chelating agents that prevent metal ions from stimulating free radical reactions, may have benefit in the treatment of FHF and its consequences.

引用

页码：139 / 144

页数：6

共 28 条

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