New insights on the role, pathogenesis, and treatment of osteoporosis and bone erosions in rheumatoid arthritis

被引:2
作者
Adami, Giovanni [1 ]
Viapiana, Ombretta [1 ]
Rossini, Maurizio [1 ]
Fassio, Angelo [1 ]
Orsolini, Giovanni [1 ]
Idolazzi, Luca [1 ]
Gatti, Davide [1 ]
机构
[1] Univ Verona, Dept Med, Rheumatol Unit, Verona, Italy
关键词
rheumatoid arthritis; osteoporosis; bone erosions; bone metabolism; synovitis;
D O I
10.11138/ccmbm/2018.15.2.177
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Bone erosions and osteoporosis are a main problem of Rheumatoid Arthritis and even in the biologic era are unsolved problems. Many hypothesis have been formulated since today on the pathogenesis of osteoporosis and bone erosions, and a new rising hypothesis is that osteoporosis and bone erosions are part of an unique pathology of bone. Our review summarizes the state of the art on osteoporosis in RA and discusses its clinical implications in terms of risk of bone erosions.
引用
收藏
页码:177 / 182
页数:6
相关论文
共 94 条
[1]   Lack of effect of teriparatide on joint erosions in rheumatoid arthritis is an expected result: comment on the article by Solomon et al [J].
Adami, Giovanni ;
Rossini, Maurizio ;
Viapiana, Ombretta ;
Fassio, Angelo ;
Idolazzi, Luca ;
Orsolini, Giovanni ;
Gatti, Davide .
ARTHRITIS & RHEUMATOLOGY, 2018, 70 (03) :475-476
[2]   Effects of TNF Inhibitors on Parathyroid Hormone and Wnt Signaling Antagonists in Rheumatoid Arthritis [J].
Adami, Giovanni ;
Orsolini, Giovanni ;
Adami, Silvano ;
Viapiana, Ombretta ;
Idolazzi, Luca ;
Gatti, Davide ;
Rossini, Maurizio .
CALCIFIED TISSUE INTERNATIONAL, 2016, 99 (04) :360-364
[3]   THE ACUTE-PHASE RESPONSE AFTER BISPHOSPHONATE ADMINISTRATION [J].
ADAMI, S ;
BHALLA, AK ;
DORIZZI, R ;
MONTESANTI, F ;
ROSINI, S ;
SALVAGNO, G ;
LOCASCIO, V .
CALCIFIED TISSUE INTERNATIONAL, 1987, 41 (06) :326-331
[4]   Relationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake [J].
Adami, Silvano ;
Viapiana, Ombretta ;
Gatti, Davide ;
Idolazzi, Luca ;
Rossini, Maurizio .
BONE, 2008, 42 (02) :267-270
[5]   Sclerostin and Its Association with Physical Activity, Age, Gender, Body Composition, and Bone Mineral Content in Healthy Adults [J].
Amrein, Karin ;
Amrein, Steven ;
Drexler, Camilla ;
Dimai, Hans Peter ;
Dobnig, Harald ;
Pfeifer, Klaus ;
Tomaschitz, Andreas ;
Pieber, Thomas R. ;
Fahrleitner-Pammer, Astrid .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (01) :148-154
[6]   The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression [J].
Atsumi, Tatsuya ;
Yamamoto, Kazuhiko ;
Takeuchi, Tsutomu ;
Yamanaka, Hisashi ;
Ishiguro, Naoki ;
Tanaka, Yoshiya ;
Eguchi, Katsumi ;
Watanabe, Akira ;
Origasa, Hideki ;
Yasuda, Shinsuke ;
Yamanishi, Yuji ;
Kita, Yasuhiko ;
Matsubara, Tsukasa ;
Iwamoto, Masahiro ;
Shoji, Toshiharu ;
Okada, Toshiyuki ;
van der Heijde, Desiree ;
Miyasaka, Nobuyuki ;
Koike, Takao .
ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (01) :75-83
[7]   Greater body mass independently predicts less radiographic progression on X-ray and MRI over 1-2 years [J].
Baker, Joshua F. ;
Ostergaard, Mikkel ;
George, Michael ;
Shults, Justine ;
Emery, Paul ;
Baker, Daniel G. ;
Conaghan, Philip G. .
ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (11) :1923-1928
[8]   Minireview:: Targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton [J].
Baron, Roland ;
Rawadi, Georges .
ENDOCRINOLOGY, 2007, 148 (06) :2635-2643
[9]   A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis [J].
Bathon, JM ;
Martin, RW ;
Fleischmann, RM ;
Tesser, JR ;
Schiff, MH ;
Keystone, EC ;
Genovese, MC ;
Wasko, MC ;
Moreland, LW ;
Weaver, AL ;
Markenson, J ;
Finck, BK .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (22) :1586-1593
[10]   Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss [J].
Bedi, Brahmchetna ;
Li, Jau-Yi ;
Grassi, Francesco ;
Tawfeek, Hesham ;
Weitzmann, M. Neale ;
Pacifici, Roberto .
SKELETAL BIOLOGY AND MEDICINE, 2010, 1192 :215-221