PREDICTION OF PLASMA-CONCENTRATIONS OF MIANSERIN AND DESMETHYLMIANSERIN AT STEADY-STATE FROM THOSE AFTER AN INITIAL DOSE OF MIANSERIN

被引：4
作者：
OTANI, K
MIHARA, K
OKADA, M
TANAKA, O
KANEKO, S
FUKUSHIMA, Y
机构：
[1] Department of Neuropsychiatry, Hirosaki University Hospital, Hirosaki
来源：
THERAPEUTIC DRUG MONITORING | 1993年 / 15卷 / 02期
关键词：
MIANSERIN; DESMETHYLMIANSERIN; PLASMA CONCENTRATION; INITIAL DOSE; STEADY STATE;
D O I：
10.1097/00007691-199304000-00009
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The relationships between the plasma concentrations of mianserin and desmethylmianserin at 18 h after initial dosing and those at steady state were studied in 19 depressed patients receiving 30 mg of mianserin at bedtime. Significant linear relationships were observed for mianserin, desmethylmianserin, and mianserin plus desmethylmianserin. The present study thus suggests that the plasma concentrations of these compounds after an initial dose of mianserin can be used for the prediction of an optimal dose.
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收藏
页码：118 / 121
页数：4
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