INHIBITION OF AZOXYMETHANE-INDUCED COLON CARCINOGENESIS IN RAT BY GREEN TEA POLYPHENOL FRACTION

被引：142

作者：

YAMANE, T ^{[1
]}

HAGIWARA, N ^{[1
]}

TATEISHI, M ^{[1
]}

AKACHI, S ^{[1
]}

KIM, M ^{[1
]}

OKUZUMI, J ^{[1
]}

KITAO, Y ^{[1
]}

INAGAKE, M ^{[1
]}

KUWATA, K ^{[1
]}

TAKAHASHI, T ^{[1
]}

机构：

[1] TAIYO KAGAKU CO LTD,CENT RES LABS,YOKKAICHI,MIE 510,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1991年 / 82卷 / 12期

关键词：

COLON CARCINOGENESIS; GREEN TEA; AZOXYMETHANE; POLYPHENOL; (-)-EPIGALLOCATECHIN GALLATE;

D O I：

10.1111/j.1349-7006.1991.tb01801.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of green tea polyphenol fraction (GTP) on azoxymethane(AOM)-induced colon carcinogenesis was investigated in male Fischer rats. The rats were given AOM (7.4 mg/kg body weight) s.c. once a week for 10 weeks. A week after the treatment, they were divided into three groups: AOM-control (26 rats), AOM-GTP1 (26 rats) and AOM-GTP2 (25 rats). AOM-GTP1 and AOM-GTP2 groups respectively received 0.01 and 0.1% GTP in drinking water from week 11 to 26. AOM-control group received tap water throughout this experiment. Autopsy on week 26 showed that tumor incidence and average numbers of tumors per rat in the AOM-GTP1 and AOM-GTP2 groups were significantly lower than those of the AOM-control group: 38.1% and 47.6% versus 77.3%; 0.6 and 0.7 versus 1.5. Thus, it was concluded that GTP inhibited the development of AOM-induced colon carcinogenesis. The inhibition by GTP did not show significant dose dependence.

引用

页码：1336 / 1339

页数：4

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