CYTOSOLIC FREE CALCIUM CONCENTRATIONS IN LYMPHOCYTES FROM MALIGNANT HYPERTHERMIA SUSCEPTIBLE PATIENTS

被引：5
作者：
ORDING, H
FODER, B
SCHARFF, O
机构：
[1] HERLEV HOSP,DEPT ANAESTHESIA,DK-2730 HERLEV,DENMARK
[2] RIGSHOSP,DEPT ANAESTHESIA,DK-2730 HERLEV,DENMARK
[3] RIGSHOSP,DEPT CLIN PHYSIOL & NUCL MED,DK-2100 COPENHAGEN O,DENMARK
来源：
BRITISH JOURNAL OF ANAESTHESIA | 1990年 / 64卷 / 03期
关键词：
Anaesthetics volatile: halothane; Hyperthermia:; malignant; lymphocytes; Lons:; calcium; intracellular;
D O I：
10.1093/bja/64.3.341
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Halothane in concentrations exceeding 1.2 mmol litre-1 increased (P < 0.05) the apparent intracellular concentration of calcium in lymphocytes from 12 patients being tested for susceptibility to malignant hyperthermia (MH) using the fluorescent Ca2+ indicator, fura2. There was no difference in [Ca2+], between lymphocytes from patients found to be MH susceptible (n = 5) on in vitro contracture testing with halothane and caffeine and those from MH negative patients (n = 6). Thus determination of [Ca2+], in lymphocytes after exposure to halothane could not be used as a diagnostic test for MH susceptibility. © 1990 British Journal of Anaesthesia.
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页码：341 / 345
页数：5
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