COFACTOR DEPENDENT AND COFACTOR INDEPENDENT ANTICARDIOLIPIN ANTIBODIES

被引：47
|
作者：
CHAMLEY, LW [1 ]
MCKAY, EJ [1 ]
PATTISON, NS [1 ]
机构：
[1] AUCKLAND HOSP,DEPT IMMUNOL,AUCKLAND 3,NEW ZEALAND
来源：
THROMBOSIS RESEARCH | 1991年 / 61卷 / 03期
关键词：
THROMBOSIS; FETAL LOSS; ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID ANTIBODIES; BETA-2; GLYCOPROTEIN-1;
D O I：
10.1016/0049-3848(91)90106-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Two distinct types of anticardiolipin antibodies are described, one of which requires the presence of a serum factor (cofactor) to bind cardiolipin in ELISA and liposome affinity systems. The second type does not require this cofactor. The requirement of a cofactor for the binding of some but not all anticardiolipin antibodies provides an explanation for the confounding variability of the results of assays for these antibodies. It also explains why blocking agents such as BSA and gelatin do not produce consistent results in this assay.
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页码：291 / 299
页数：9
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