AMPHIPHILIC CHOLESTEROL CONTAINING POLYMERS FOR DRUG DELIVERY SYSTEMS

被引：3

作者：

Demchuk, Zoriana ^{[1
]}

Savka, Mariya ^{[1
]}

Voronov, Andriy ^{[2
]}

Budishevska, Olga ^{[1
]}

Donchak, Volodymyr ^{[1
]}

Voronov, Stanislav ^{[1
]}

机构：

[1] Lviv Polytech Natl Univ, 12 S Bandery St, UA-79013 Lvov, Ukraine

[2] North Dakota State Univ, 1735 NDSU Res Pk Dr, Fargo, ND 58102 USA

来源：

CHEMISTRY & CHEMICAL TECHNOLOGY | 2016年 / 10卷 / 04期

关键词：

amphiphilic polymers; cholesterol; solubilization; drug delivery systems;

D O I：

10.23939/chcht10.04si.561

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interaction of binary copolymers poly(maleic anhydride-co-poly(ethylene glycol) methyl ether methacrylate) with cholesterol results in formation of cholesterol containing polymers, which contain from 4.6 to 46.0 mol % monocholesteryl maleic links. Their structure was confirmed using functional analysis and IR spectroscopy. Acidic and anhydride links of these copolymers form polymeric salts if react with alkali. These salts are surfactants which in aqueous medium form hierarchy micelles and micellar aggregates depending on the copolymer concentration. Using conductometry it was found that preferably monomolecular micelles are formed in dilute solutions, and micellar aggregates begin to form at higher concentrations. In aqueous media polymeric salts are able to solubilize such lipophilic substances as Sudan III dye and anticancer drug curcumin. Efficiency of solubilization towards Sudan III grows if the content of monocholesteryl maleic fragment in surfactant increases.

引用

页码：561 / 570

页数：10

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