CONCISE CHEMICAL SYNTHESIS OF BETA-HOMONOJIRIMYCIN AND RELATED-COMPOUNDS

被引：42

作者：

MARTIN, OR

SAAVEDRA, OM

机构：

[1] Department of Chemistry, State University of New York, Binghamton

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 06期

关键词：

D O I：

10.1016/0040-4039(94)02389-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Homonojirimycin 2 was prepared in 27% overall yield from tetra-O-benzyl-D-glucono-1,5-lactone by way of the double reductive amination of a 2,6-heptodiulose (7). This synthetic approach provided also access to the 1,N-anhydro derivative of 2, compound 3. Aziridines of this type are potential inactivators of glycosidases.

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页码：799 / 802

页数：4

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