DCC - LINKING TUMOR-SUPPRESSOR GENES AND ALTERED CELL-SURFACE INTERACTIONS IN CANCER

被引：66

作者：

CHO, KR ^{[1
]}

FEARON, ER ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, BOYER CTR MOLEC MED, NEW HAVEN, CT 06536 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(95)90056-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The gene deleted in colorectal cancer (DCC) is a candidate tumor suppressor gene encoding a neural cell adhesion molecule like transmembrane protein. Over the past year, data supporting DCC inactivation in multiple tumor types have continued to accumulate. Functional studies suggest that DCC may participate in signaling pathways that regulate cell proliferation and/or differentiation, two cellular processes that often go awry during tumorigenesis.

引用

页码：72 / 78

页数：7

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