Amnion graft as a possible source of stem cells for endometrial regeneration after lysis of severe intrauterine adhesions

被引：12
作者：
Amer, Mohamed [1 ,3 ]
Abd-El-Maeboud, Karim [1 ]
Alloub, Amal [2 ]
机构：
[1] Ain Shams Univ, Fac Med, Dept Obstet & Gynaecol, Cairo, Egypt
[2] Ain Shams Univ, Fac Med, Dept Pathol, Cairo, Egypt
[3] Ain Shams Univ, Fac Med, Dept OB GYN, Abbassia, Cairo, Egypt
来源：
MIDDLE EAST FERTILITY SOCIETY JOURNAL | 2012年 / 17卷 / 01期
关键词：
Intrauterine adhesions; Amnion graft; Stem cells;
D O I：
10.1016/j.mefs.2011.12.001
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: The current traditional management of severe intrauterine adhesions (IUAs) is hysteroscopic adhesiolysis with application of either an intrauterine contraceptive device or a Foley catheter balloon with reported recurrence in up to 50% of cases. Recently, significant improvement with the use of amnion graft following hysteroscopic lysis of severe IUA was reported. Case: In the present case, endometrial stromal cells (ESCs) were found within and on the surface of amniotic membrane two months after its grafting intrauterine which was confirmed with CD10 immunohistochemistry. Conclusion: Amniotic membrane graft after hysteroscopic lysis of severe IUA, might act as a source of stem cells for endometrial regeneration; a role that will be of great value especially in severe IUAs. Further studies to confirm this finding are warranted. (C) 2011 Middle East Fertility Society. Production and hosting by Elsevier B.V. All rights reserved.
引用
收藏
页码：54 / 56
页数：3
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