PATTERNING OF THE CAENORHABDITIS-ELEGANS HEAD REGION BY THE PAX-6 FAMILY MEMBER VAB-3

被引：139
作者：
CHISHOLM, AD
HORVITZ, HR
机构：
[1] Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, 68-425
来源：
NATURE | 1995年 / 377卷 / 6544期
关键词：
D O I：
10.1038/377052a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
THE Pax-6 genes are important for eye development in both vertebrates and Drosophila. Mutations in the human PAX6 gene are found in patients with a variety of eye disorders, including aniridia and Peters' anomaly(1-3), and mutations in the Drosophila Pax-6 homologue cause the eyeless phenotype(4). In the nematode Caenorhabditis elegans, vab-3 mutants display many defects in head-region development, including aberrant morphogenesis, transformation of hypodermal (epidermal-like) cell fates to those of posterior homologues, and abnormal specification of neurons, Here we show that vab-3 is a member of the Pax-6 gene family and is expressed in head-region cells, This C. elegans Pax-6 locus can also encode proteins lacking the paired domain(5). Our results suggest: that. a primordial role of the Pax-6 gene family could have been to pattern part of the head region, and that Pax-6 genes subsequently evolved to be more specifically involved in eye development.
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页码：52 / 55
页数：4
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