NADPH OXIDASE IS NOT ESSENTIAL FOR LOW-DENSITY-LIPOPROTEIN OXIDATION BY HUMAN MONOCYTE-DERIVED MACROPHAGES

被引：8

作者：

WILKINS, GM ^{[1
]}

SEGAL, AW ^{[1
]}

LEAKE, DS ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL, RAYNE INST, DEPT MED, LONDON WC1E 6JJ, ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/bbrc.1994.2072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NADPH oxidase has been reported to be involved in low density lipoprotein (LDL) oxidation by monocytes. We have investigated the ability of monocyte-derived macrophages from four chronic granulomatous disease patients, which lack NADPH oxidase, to oxidise LDL. All the cells oxidised LDL to significantly mouse macrophages. We conclude therefore that NADPH oxidase is oxidation by macrophages. (C) 1994 Academic Press, Inc.

引用

页码：1300 / 1307

页数：8

共 29 条

[1] FLAVONOIDS INHIBIT THE OXIDATIVE MODIFICATION OF LOW-DENSITY LIPOPROTEINS BY MACROPHAGES [J].

DEWHALLEY, CV ;

RANKIN, SM ;

HOULT, JRS ;

JESSUP, W ;

LEAKE, DS .

BIOCHEMICAL PHARMACOLOGY, 1990, 39 (11) :1743-1750

[2]

GEY KF, 1989, ANN NY ACAD SCI, V570, P268

[3] THE INHIBITION BY DIPHENYLENEIODONIUM AND ITS ANALOGS OF SUPEROXIDE GENERATION BY MACROPHAGES [J].

HANCOCK, JT ;

JONES, OTG .

BIOCHEMICAL JOURNAL, 1987, 242 (01) :103-107

[4]

HEINECKE JW, 1987, J BIOL CHEM, V262, P10098

[5] SUPEROXIDE-MEDIATED MODIFICATION OF LOW-DENSITY-LIPOPROTEIN BY ARTERIAL SMOOTH-MUSCLE CELLS [J].

HEINECKE, JW ;

BAKER, L ;

ROSEN, H ;

CHAIT, A .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (03) :757-761

[6] ENHANCED MACROPHAGE DEGRADATION OF BIOLOGICALLY MODIFIED LOW-DENSITY LIPOPROTEIN [J].

HENRIKSEN, T ;

MAHONEY, EM ;

STEINBERG, D .

ARTERIOSCLEROSIS, 1983, 3 (02) :149-159

[7] ENHANCED MACROPHAGE DEGRADATION OF LOW-DENSITY LIPOPROTEIN PREVIOUSLY INCUBATED WITH CULTURED ENDOTHELIAL-CELLS - RECOGNITION BY RECEPTORS FOR ACETYLATED LOW-DENSITY LIPOPROTEINS [J].

HENRIKSEN, T ;

MAHONEY, EM ;

STEINBERG, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6499-6503

[8] SUPEROXIDE INITIATES OXIDATION OF LOW-DENSITY-LIPOPROTEIN BY HUMAN-MONOCYTES [J].

HIRAMATSU, K ;

ROSEN, H ;

HEINECKE, JW ;

WOLFBAUER, G ;

CHAIT, A .

ARTERIOSCLEROSIS, 1987, 7 (01) :55-60

[9] ALPHA-TOCOPHEROL CONSUMPTION DURING LOW-DENSITY-LIPOPROTEIN OXIDATION [J].

JESSUP, W ;

RANKIN, SM ;

DEWHALLEY, CV ;

HOULT, JRS ;

SCOTT, J ;

LEAKE, DS .

BIOCHEMICAL JOURNAL, 1990, 265 (02) :399-405

[10] DOES SUPEROXIDE RADICAL HAVE A ROLE IN MACROPHAGE-MEDIATED OXIDATIVE MODIFICATION OF LDL [J].

JESSUP, W ;

SIMPSON, JA ;

DEAN, RT .

ATHEROSCLEROSIS, 1993, 99 (01) :107-120

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