ANTIBODIES AND COMPLEMENT ENHANCE BINDING AND UPTAKE OF HIV-1 BY HUMAN MONOCYTES

被引:29
作者
BAKKER, LJ [1 ]
NOTTET, HSLM [1 ]
DEVOS, NM [1 ]
DEGRAAF, L [1 ]
VANSTRIJP, JAG [1 ]
VISSER, MR [1 ]
VERHOEF, J [1 ]
机构
[1] UNIV HOSP UTRECHT,EIJKMAN WINKLER LAB MED MICROBIOL,UTRECHT,NETHERLANDS
关键词
MONOCYTE; NEUTROPHIL; HIV-1; BINDING; COMPLEMENT; ANTIBODY; OPSONIZATION; PHAGOCYTOSIS; FLOW CYTOMETRY;
D O I
10.1097/00002030-199201000-00004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To characterize antibody- and complement-mediated binding and uptake of HIV-1 by human monocytes. Design: The first step in the infection of the monocyte by HIV-1 is binding of the virus to the susceptible cell. Procedures were designed to assess the influence of anti-HIV-1 antibodies and complement on this binding, and to study the process of internalization following binding. Methods: Human monocytes were incubated with fluorescein-labelled purified HTLV-III(B) virions and human sera with high-titre anti-HIV-1 antibodies and/or complement. Binding and uptake of virus by the monocytes was measured as fluorescence per cell by flow cytometry. Results: Binding of purified HIV-1 to monocytes was increased by complement and, to a lesser extent, by anti-HIV-1 antibodies. Uptake of HIV-1 bound to the monocyte appeared to be mediated by antibodies and was increased further by the presence of complement. Complement alone, however, resulted in the uptake of only a small part of the bound virus. Conclusions: Complement significantly increases the binding of HIV-1 to human monocytes, and a combination of antibodies and complement efficiently mediates uptake of HIV-1 monocytes.
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页码:35 / 41
页数:7
相关论文
共 27 条
[1]   THE AIDS-ASSOCIATED RETROVIRUS IS NOT SENSITIVE TO LYSIS OR INACTIVATION BY HUMAN-SERUM [J].
BANAPOUR, B ;
SERNATINGER, J ;
LEVY, JA .
VIROLOGY, 1986, 152 (01) :268-271
[2]   INFECTION OF MONOCYTE-DERIVED MACROPHAGES WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) - MONOCYTE-TROPIC AND LYMPHOCYTE-TROPIC STRAINS OF HIV-1 SHOW DISTINCTIVE PATTERNS OF REPLICATION IN A PANEL OF CELL-TYPES [J].
COLLMAN, R ;
HASSAN, NF ;
WALKER, R ;
GODFREY, B ;
CUTILLI, J ;
HASTINGS, JC ;
FRIEDMAN, H ;
DOUGLAS, SD ;
NATHANSON, N .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1149-1163
[3]   THE ROLE OF MONONUCLEAR PHAGOCYTES IN HTLV-III LAV INFECTION [J].
GARTNER, S ;
MARKOVITS, P ;
MARKOVITZ, DM ;
KAPLAN, MH ;
GALLO, RC ;
POPOVIC, M .
SCIENCE, 1986, 233 (4760) :215-219
[4]   EFFICIENT ISOLATION AND PROPAGATION OF HUMAN IMMUNODEFICIENCY VIRUS ON RECOMBINANT COLONY-STIMULATING FACTOR-1-TREATED MONOCYTES [J].
GENDELMAN, HE ;
ORENSTEIN, JM ;
MARTIN, MA ;
FERRUA, C ;
MITRA, R ;
PHIPPS, T ;
WAHL, LA ;
LANE, HC ;
FAUCI, AS ;
BURKE, DS ;
SKILLMAN, D ;
MELTZER, MS .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (04) :1428-1441
[5]  
HALSTEAD SB, 1988, SCIENCE, V239, P476, DOI 10.1126/science.3277268
[6]   INFECTION OF MONOCYTE MACROPHAGES BY HUMAN T-LYMPHOTROPIC VIRUS TYPE-III [J].
HO, DD ;
ROTA, TR ;
HIRSCH, MS .
JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (05) :1712-1715
[7]   THE FC AND NOT CD4 RECEPTOR MEDIATES ANTIBODY ENHANCEMENT OF HIV INFECTION IN HUMAN-CELLS [J].
HOMSY, J ;
MEYER, M ;
TATENO, M ;
CLARKSON, S ;
LEVY, JA .
SCIENCE, 1989, 244 (4910) :1357-1360
[8]  
HOSOI S, 1990, J ACQ IMMUN DEF SYND, V3, P366
[9]   HIV INFECTION OF MONOCYTIC CELLS - ROLE OF ANTIBODY-MEDIATED VIRUS BINDING TO FC-GAMMA-RECEPTORS [J].
JOUAULT, T ;
CHAPUIS, F ;
OLIVIER, R ;
PARRAVICINI, C ;
BAHRAOUI, E ;
GLUCKMAN, JC .
AIDS, 1989, 3 (03) :125-133
[10]   HUMAN EOSINOPHILS EXPRESS CD4 PROTEIN AND BIND HUMAN IMMUNODEFICIENCY VIRUS-1 GP120 [J].
LUCEY, DR ;
DORSKY, DI ;
NICHOLSONWELLER, A ;
WELLER, PF .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) :327-332