THE 4-NITROQUINOLINE 1-OXIDE MUTATIONAL SPECTRUM IN SINGLE-STRANDED-DNA IS CHARACTERIZED BY GUANINE TO PYRIMIDINE TRANSVERSIONS

被引:40
作者
FRONZA, G [1 ]
CAMPOMENOSI, P [1 ]
IANNONE, R [1 ]
ABBONDANDOLO, A [1 ]
机构
[1] UNIV GENOA,CATTEDRA GENET,I-16126 GENOA,ITALY
关键词
D O I
10.1093/nar/20.6.1283
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
4-Nitroquinoline-1-oxide is a potent mutagen and carcinogen which induces two main guanine adducts at positions C8 and N2. In ds or ss damaged DNA the ratio C8/N2 adducts is 1:2 and 8 - 10:1, respectively. In bacteria and yeast 4NQO has been shown to be a base substitution mutagen acting at G residues inducing mainly G to A transitions. We determined the mutational spectrum induced by the 4NQO metabolite, acetoxy-4-aminoquinoline 1-oxide, in the M13lacZ'/E.coli lacZ-DELTA-M15 alpha complementation assay using ssDNA. Among 68 Ac-4HAQO induced mutants, G to Pyr transversion was the most frequent base substitution observed. By comparison with dsDNA based systems, our data suggest that dGuo-C8-AQO induces G to Pyr transversions. A mechanism to explain how this lesion may induce transversions is proposed.
引用
收藏
页码:1283 / 1287
页数:5
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