Neutrophil Gelatinase-Associated Lipocalin And Omentin As Biomarkers Of Chronic Kidney Disease

The prevalence of End Stage Renal Disease (ESRD) has been increasing worldwide. It is an important health problem which causes high mortality and morbidity. The main pathophysiologic mechanism underlying the high mortality of ESRD is premature atherosclerosis and chronic inflammation. A large number of biomolecules have been shown to predict the atherosclerotic and inflammatory process in ESRD. To investigate the level of Omentin and Neutrophil gelatinase - associated lipocalin (NGAL) in patients with ESRD receiving hemodialysis. The present study included 60 patients with end stage renal disease(ESRD) in addition 30normal healthy individuals were enrolled in this study as control group. This study revealed that there was high significant with the mean level of Omentin 1 concentration in ESRD group (488,38 +/- 371,08 p< 0.001) in compared to healthy group, also there was significant elevation in the mean level of NGAL (902,90 +/- 698,35 p< 0.001). Omentin and NGAL were consider better markers of End Stage Renal Disease.