RIGIDIN, A NOVEL ALKALOID WITH CALMODULIN ANTAGONISTIC ACTIVITY FROM THE OKINAWAN MARINE TUNICATE EUDISTOMA CF RIGIDA

被引：65
作者：
KOBAYASHI, J
CHENG, JF
KIKUCHI, Y
ISHIBASHI, M
YAMAMURA, S
OHIZUMI, Y
OHTA, T
NOZOE, S
机构：
[1] KEIO UNIV,FAC SCI & TECHNOL,YOKOHAMA,KANAGAWA 223,JAPAN
[2] MITSUBISHI KASEI INST LIFE SCI,MACHIDA,TOKYO 194,JAPAN
[3] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN
来源：
TETRAHEDRON LETTERS | 1990年 / 31卷 / 32期
关键词：
D O I：
10.1016/S0040-4039(00)97690-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel pyrrolopyrimidine alkaloid, rigidin (1), with calmodulin antagonistic activity has been isolated from the Okinawan marine tunicate Eudistoma cf. rigida. The structure was elucidated on the basis of spectral data of 1 and its pentamethyl derivative (2). © 1990.
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页码：4617 / 4620
页数：4
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