METABOLIC N-OXIDATION OF 3-SUBSTITUTED PYRIDINES - IDENTIFICATION OF PRODUCTS BY MASS-SPECTROMETRY

被引：35

作者：

COWAN, DA

DAMANI, LA

GORROD, JW

机构：

[1] Department of Pharmacy, Chelsea College, University of London, London, SW3 6LX, Manresa Road

[2] University College Hospital Medical School, Laboratory of Toxicology and Pharmacokinetics, London, WC1 6JJ, University Street

来源：

BIOMEDICAL MASS SPECTROMETRY | 1978年 / 5卷 / 09期

关键词：

D O I：

10.1002/bms.1200050909

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The mass spectral characteristics of the N‐oxides of a range of 3‐substituted pyridines, and of quinoline and isoquinoline, are described. The molecular ion is the base peak in the majority of cases, provided that thermolysis is minimized when using the direct probe or gas chromatograph inlets. Chromatographic and mass spectral evidence is presented which indicates that biological oxidation of the heteroaromatic nitrogen of 3‐substituted pyridines is a route of metabolism in vivo and in vitro. Copyright © 1978 Heyden & Son Ltd

引用

页码：551 / 556

页数：6

共 32 条

[1]

BECKETT A. H., 1966, DANSK TEDSSKR FARM, V40, P197

[2] ANALYSIS OF NICOTINE-1'-N-OXIDE IN URINE, IN PRESENCE OF NICOTINE AND COTININE, AND ITS APPLICATION TO STUDY OF IN-VIVO NICOTINE METABOLISM IN MAN [J].