LAMOTRIGINE VERSUS OTHER ANTIEPILEPTIC DRUGS - A STAR RATING SYSTEM IS BORN

被引：37
作者：
BRODIE, MJ
机构：
[1] Epilepsy Research Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow
来源：
EPILEPSIA | 1994年 / 35卷
关键词：
ANTICONVULSANTS; DRUG INTERACTIONS; LAMOTRIGINE; DRUG TOXICITY; PHARMACOKINETICS;
D O I：
10.1111/j.1528-1157.1994.tb05966.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
With the launching worldwide of a range of new antiepileptic drugs (AEDs), the prescriber has a much wider choice than ever before. Comparative studies between new and established AEDs are few, and those between new AEDs are rarely performed. This report considers the strengths and weaknesses of nine new and established AEDs. Scores ranging from -2 to +2 are given under six headings: mechanism of action, pharmacokinetics, efficacy, side effects, drug interactions, and a comfort factor. Perceived advantages and disadvantages in their clinical use are summarized and a final ''star rating'' produced for each. This process is illustrated by a detailed critique of lamotrigine (LTG). The star system is intended to stimulate dialogue among epileptologists in reaching a consensus in the pharmacologic management of the epileptic patient.
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收藏
页码：S41 / S46
页数：6
相关论文
共 22 条
[1]   DOUBLE-BLIND CROSSOVER TRIAL OF LAMOTRIGINE (LAMICTAL) AS ADD-ON THERAPY IN INTRACTABLE EPILEPSY [J].
BINNIE, CD ;
DEBETS, RMC ;
ENGELSMAN, M ;
MEIJER, JWA ;
MEINARDI, H ;
OVERWEG, J ;
PECK, AW ;
VANWIERINGEN, A ;
YUEN, WC .
EPILEPSY RESEARCH, 1989, 4 (03) :222-229
[2]   DRUG-INTERACTIONS IN EPILEPSY [J].
BRODIE, MJ .
EPILEPSIA, 1992, 33 :S13-S22
[3]   LAMOTRIGINE [J].
BRODIE, MJ .
LANCET, 1992, 339 (8806) :1397-1400
[4]  
BRODIE MJ, 1993, LAMOTRIGINE NEW ADV, V204, P83
[5]   LAMOTRIGINE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND CLINICAL EFFICACY IN EPILEPSY [J].
GOA, KL ;
ROSS, SR ;
CHRISP, P .
DRUGS, 1993, 46 (01) :152-176
[6]   LAMOTRIGINE - SINGLE-DOSE PHARMACOKINETICS AND INITIAL 1 WEEK EXPERIENCE IN REFRACTORY EPILEPSY [J].
JAWAD, S ;
YUEN, WC ;
PECK, AW ;
HAMILTON, MJ ;
OXLEY, JR ;
RICHENS, A .
EPILEPSY RESEARCH, 1987, 1 (03) :194-201
[7]   PHARMACOLOGICAL STUDIES ON LAMOTRIGINE, A NOVEL POTENTIAL ANTIEPILEPTIC DRUG .2. NEUROCHEMICAL STUDIES ON THE MECHANISM OF ACTION [J].
LEACH, MJ ;
MARDEN, CM ;
MILLER, AA .
EPILEPSIA, 1986, 27 (05) :490-497
[8]   A COMPARISON OF VALPROATE WITH CARBAMAZEPINE FOR THE TREATMENT OF COMPLEX PARTIAL SEIZURES AND SECONDARILY GENERALIZED TONIC CLONIC SEIZURES IN ADULTS [J].
MATTSON, RH ;
CRAMER, JA ;
COLLINS, JF .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (11) :765-771
[9]   COMPARISON OF CARBAMAZEPINE, PHENOBARBITAL, PHENYTOIN, AND PRIMIDONE IN PARTIAL AND SECONDARILY GENERALIZED TONIC CLONIC SEIZURES [J].
MATTSON, RH ;
CRAMER, JA ;
COLLINS, JF ;
SMITH, DB ;
DELGADOESCUETA, AV ;
BROWNE, TR ;
WILLIAMSON, PD ;
TREIMAN, DM ;
MCNAMARA, JO ;
MCCUTCHEN, CB ;
HOMAN, RW ;
CRILL, WE ;
LUBOZYNSKI, MF ;
ROSENTHAL, NP ;
MAYERSDORF, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (03) :145-151
[10]   DRUG-INTERACTIONS THAT MATTER - A CRITICAL REAPPRAISAL [J].
MCINNES, GT ;
BRODIE, MJ .
DRUGS, 1988, 36 (01) :83-110
123