SCREEN FOR ENHANCERS OF POLYCOMB AND POLYCOMBLIKE IN DROSOPHILA-MELANOGASTER

被引：37

作者：

LANDECKER, HL ^{[1
]}

SINCLAIR, DAR ^{[1
]}

BROCK, HW ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT ZOOL,VANCOUVER V6T 1Z4,BC,CANADA

来源：

DEVELOPMENTAL GENETICS | 1994年 / 15卷 / 05期

关键词：

POLYCOMB GROUP; HOMEOTIC; SPALT; DEVENIR; SU(PC)37D;

D O I：

10.1002/dvg.1020150505

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There are 11 Polycomb group genes known in Drosophila. These genes are negative regulators of homeotic gene expression, and may act by modifying chromatin structure. It is not clear how many members of the Polycomb group of genes exist. Many were discovered because of their homeotic phenotypes, or because they enhance homeotic mutations. Systematic screens for enhancers of Polycomb have identified previously known members of the Polycomb group. In an attempt to discover cytological locations of new Polycomb group genes, we crossed deletions uncovering about 20% of the genome to Polycomb-like and Polycomb and scored for enhancement of the extra sex combs phenotype. Haploidy for four regions, 36F7-37A, 43E18; 44B5-9, 70C2-6, and 70C6-15; 70D enhanced the extra sex comb phe notype associated with strong Polycomb group mutations. These regions have homeotic phenotypes either as homozygous embryos or heterozygous adults, or both. We also show that spalt enhances Polycomb group mutations. These results are discussed with respect to previous estimates of Polycomb group gene number. (C) 1994 Wiley-Liss, Inc.

引用

页码：425 / 434

页数：10

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