ENANTIOMER RESOLUTION BY USING CAPILLARY ZONE ELECTROPHORESIS - RESOLUTION OF RACEMIC TRYPTOPHAN AND DETERMINATION OF THE ENANTIOMER COMPOSITION OF COMMERCIAL PHARMACEUTICAL EPINEPHRINE

被引：154

作者：

FANALI, S ^{[1
]}

BOCEK, P ^{[1
]}

机构：

[1] CZECHOSLOVAK ACAD SCI, INST ANALYT CHEM, BRNO, CZECHOSLOVAKIA

来源：

ELECTROPHORESIS | 1990年 / 11卷 / 09期

关键词：

D O I：

10.1002/elps.1150110913

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomers of D‐ and L‐tryptophan were separated by capillary electrophoresis, using α‐cyclodextrin as a chiral active component in the background electrolyte. The separation of (‐) and (+) epinephrine was achieved by supplementing the background electrolyte with Heptakis (2,6‐di‐O‐methyl‐β‐cyclodextrin). As a practical application of the method, the quantitative analysis of (‐)and(+)enantiomers in commercial pharmaceutical solutions of adrenaline is shown. Copyright © 1990 VCH Verlagsgesellschaft mbH

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页码：757 / 760

页数：4

相关论文

共 19 条

[1] USE OF HYDROXYPROPYL-DERIVATIZED AND HYDROXYETHYL-DERIVATIZED BETA-CYCLODEXTRINS FOR THE THIN-LAYER CHROMATOGRAPHIC-SEPARATION OF ENANTIOMERS AND DIASTEREOMERS [J].

ARMSTRONG, DW ;

FAULKNER, JR ;

HAN, SM .

JOURNAL OF CHROMATOGRAPHY, 1988, 452 :323-330

[2] DIRECT LIQUID-CHROMATOGRAPHIC SEPARATION OF RACEMATES WITH AN ALPHA-CYCLODEXTRIN BONDED PHASE [J].

ARMSTRONG, DW ;

YANG, XF ;

HAN, SM ;

MENGES, RA .

ANALYTICAL CHEMISTRY, 1987, 59 (21) :2594-2596

[3] HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS USING OPEN TUBES AND GELS [J].

COHEN, AS ;

PAULUS, A ;

KARGER, BL .

CHROMATOGRAPHIA, 1987, 24 :15-24

[4] ENANTIOSELECTIVE HYDROPHOBIC ENTANGLEMENT OF ENANTIOMERIC SOLUTES WITH CHIRAL FUNCTIONALIZED MICELLES BY ELECTROKINETIC CHROMATOGRAPHY [J].

DOBASHI, A ;

ONO, T ;

HARA, S ;

YAMAGUCHI, J .

JOURNAL OF CHROMATOGRAPHY, 1989, 480 :413-420

[5] SEPARATION OF OPTICAL ISOMERS BY CAPILLARY ZONE ELECTROPHORESIS BASED ON HOST GUEST COMPLEXATION WITH CYCLODEXTRINS [J].

FANALI, S .

JOURNAL OF CHROMATOGRAPHY, 1989, 474 (02) :441-446

[6]

FANALI S, 1989, J MICROCOLUMN SEP, V1, P192

[7] OPTICAL RESOLUTION OF SOME MANDELIC DERIVATIVES ON A CHEMICALLY BONDED CYCLODEXTRIN STATIONARY PHASE [J].

FUJIMURA, K ;

KITAGAWA, M ;

TAKAYANAGI, H ;

ANDO, T .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3) :607-620

[8] ELECTROKINETIC SEPARATION OF CHIRAL COMPOUNDS [J].

GASSMANN, E ;

KUO, JE ;

ZARE, RN .

SCIENCE, 1985, 230 (4727) :813-814

[9] ELECTROKINETIC RESOLUTION OF AMINO-ACID ENANTIOMERS WITH COPPER(II) ASPARTAME SUPPORT ELECTROLYTE [J].

GOZEL, P ;

GASSMANN, E ;

MICHELSEN, H ;

ZARE, RN .

ANALYTICAL CHEMISTRY, 1987, 59 (01) :44-49

[10] USE OF COMPLEXING AGENTS FOR SELECTIVE SEPARATION IN HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS - CHIRAL RESOLUTION VIA CYCLODEXTRINS INCORPORATED WITHIN POLYACRYLAMIDE-GEL COLUMNS [J].

GUTTMAN, A ;

PAULUS, A ;

COHEN, AS ;

GRINBERG, N ;

KARGER, BL .

JOURNAL OF CHROMATOGRAPHY, 1988, 448 (01) :41-53