THE ROLE OF PARATHYROID HORMONE-RELATED PROTEIN IN CALCIUM HOMEOSTASIS IN THE FETAL PIG

被引：11
|
作者：
ABBAS, SK
RATCLIFFE, WA
MONIZ, C
DIXIT, M
CAPLE, IW
SILVER, M
FOWDEN, A
CARE, AD
机构：
[1] UNIV WALES,INST BIOL SCI,ABERYSTWYTH SY23 3DD,DYFED,WALES
[2] QUEEN ELIZABETH MED CTR,WOLFSON RES LABS,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND
[3] UNIV LONDON KINGS COLL HOSP,DEPT CHEM PATHOL,LONDON SE5 9RS,ENGLAND
[4] UNIV MELBOURNE,DEPT VET CLIN SCI,MELBOURNE,VIC 3030,AUSTRALIA
[5] UNIV CAMBRIDGE,PHYSIOL LAB,CAMBRIDGE CB2 3EG,ENGLAND
来源：
EXPERIMENTAL PHYSIOLOGY | 1994年 / 79卷 / 04期
基金：
英国惠康基金;
关键词：
D O I：
10.1113/expphysiol.1994.sp003785
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The concentrations of plasma parathyroid hormone-like bioactivity and parathyroid hormone-related protein (1-86) (PTHrP) immunoreactivity were both higher in fetal pigs than in their mothers during the last 3 weeks of gestation. Both activities changed inversely with alterations in the plasma ionized calcium concentration. The data suggest that PTHrP may have a role in calcium homeostasis in the fetal pig, similar to its postulated role in sheep in the stimulation of calcium transport across the placenta.
引用
收藏
页码：527 / 536
页数：10
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