MOLECULAR-CLONING AND CHARACTERIZATION OF THE GENE ENCODING THE MURINE D-4 DOPAMINE-RECEPTOR

被引：0

作者：

FISHBURN, CS ^{[1
]}

CARMON, S ^{[1
]}

FUCHS, S ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL

来源：

FEBS LETTERS | 1995年 / 361卷 / 2-3期

关键词：

MURINE D-4 RECEPTOR; ANTIPSYCHOTIC DRUG; NEUROPATHOLOGICAL DISEASE; GENE ORGANIZATION; DOPAMINE; G PROTEIN-LINKED RECEPTOR;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The murine D-4 dopamine receptor was isolated from a murine genomic DNA library, The receptor's entire coding region was contained within a 6 kb EcoRI genomic fragment, indicating that the murine D-4 receptor gene is significantly smaller than the corresponding D-2 and D-3 receptor genes, the coding regions of which each stretch over 30 kb. The murine D-4 receptor gene has three introns and four exons, in common with the rat and human D-4 receptor genes. RT-PCR on mRNA from different brain regions shows that the D-4 receptor mRNA is expressed in various areas of the brain, with some differences from the rat and human receptor homologues.

引用

页码：215 / 219

页数：5

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