GENETIC-EVIDENCE THAT RI CHLOROQUINE RESISTANCE OF PLASMODIUM-FALCIPARUM IS CAUSED BY RECRUDESCENCE OF RESISTANT PARASITES

被引：53
作者：
BABIKER, H
RANFORDCARTWRIGHT, L
SULTAN, A
SATTI, G
WALLIKER, D
机构：
[1] MINIST HLTH SUDAN,DEPT MALARIA ADM,KHARTOUM,SUDAN
[2] UNIV KHARTOUM,FAC MED,DEPT BIOCHEM,KHARTOUM,SUDAN
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 88卷 / 03期
关键词：
D O I：
10.1016/0035-9203(94)90103-1
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Isolates of Plasmondium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.
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页码：328 / 331
页数：4
相关论文
共 16 条
[1]   GENETIC DIVERSITY OF PLASMODIUM-FALCIPARUM IN A VILLAGE IN EASTERN SUDAN .1. DIVERSITY OF ENZYMES, 2D-PAGE PROTEINS AND ANTIGENS [J].
BABIKER, HA ;
CREASEY, AM ;
FENTON, B ;
BAYOUMI, RAL ;
ARNOT, DE ;
WALLIKER, D .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (05) :572-577
[2]   GENETIC DIVERSITY OF PLASMODIUM-FALCIPARUM IN A VILLAGE IN EASTERN SUDAN .2. DRUG-RESISTANCE, MOLECULAR KARYOTYPES AND THE MDR1 GENOTYPE OF RECENT ISOLATES [J].
BABIKER, HA ;
CREASEY, AM ;
BAYOUMI, RAL ;
WALLIKER, D ;
ARNOT, DE .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (05) :578-583
[3]   CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM IN EASTERN SUDAN [J].
BAYOUMI, RA ;
BABIKER, HA ;
IBRAHIM, SM ;
GHALIB, HW ;
SAEED, BO ;
KHIDER, S ;
ELWASILA, M ;
KARIM, EA .
ACTA TROPICA, 1989, 46 (03) :157-165
[4]  
Bruce-Chwatt LJ, 1986, CHEMOTHERAPY MALARIA
[5]  
ELGADDAL A, 1986, P C MALARIA AFRICA, P156
[6]   STRUCTURAL AND ANTIGENIC POLYMORPHISM OF THE 35-KILODALTON TO 48-KILODALTON MEROZOITE SURFACE-ANTIGEN (MSA-2) OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM [J].
FENTON, B ;
CLARK, JT ;
KHAN, CMA ;
ROBINSON, JV ;
WALLIKER, D ;
RIDLEY, R ;
SCAIFE, JG ;
MCBRIDE, JS .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (02) :963-971
[7]   RAPID AND SIMPLE METHOD FOR ISOLATING MALARIA DNA FROM FINGERPRICK SAMPLES OF BLOOD [J].
FOLEY, M ;
RANFORDCARTWRIGHT, LC ;
BABIKER, HA .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1992, 53 (1-2) :241-244
[8]   PCR DETECTION OF PLASMODIUM-FALCIPARUM BY OLIGONUCLEOTIDE PROBES [J].
JAUREGUIBERRY, G ;
HATIN, I ;
DAURIOL, L ;
GALIBERT, G .
MOLECULAR AND CELLULAR PROBES, 1990, 4 (05) :409-414
[9]   GENETIC DIVERSITY IN THE MAJOR MEROZOITE SURFACE-ANTIGEN OF PLASMODIUM-FALCIPARUM - HIGH PREVALENCE OF A 3RD POLYMORPHIC FORM DETECTED IN STRAINS DERIVED FROM MALARIA PATIENTS [J].
KIMURA, E ;
MATTEI, D ;
DISANTI, SM ;
SCHERF, A .
GENE, 1990, 91 (01) :57-62
[10]   FOR A FEW PARASITES MORE - INOCULUM SIZE, VECTOR CONTROL AND STRAIN-SPECIFIC IMMUNITY TO MALARIA [J].
LINES, J ;
ARMSTRONG, JRM .
PARASITOLOGY TODAY, 1992, 8 (11) :381-383
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