PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer

被引：3

作者：

Takeda, Kana ^{[1
]}

Fujimura, Taku ^{[1
]}

Lyu, Chunbing ^{[1
]}

Tsukada, Akira ^{[1
]}

Tsuchiyama, Kenichiro ^{[1
]}

Hashimoto, Akira ^{[1
]}

Aiba, Setsuya ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Miyagi, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2018年 / 11卷 / 02期

关键词：

Radiation-associated angiosarcoma; PD-L1; Cutaneous angiosarcoma; MMP9; Prognostic factors;

D O I：

10.1159/000489628

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation-associated angiosarcoma (RAAS) is a type of radiation-associated sarcoma (RAS) that develops at the previous field of radiation in breast cancer patients. Although several reports have suggested a poor prognosis for RAAS, the 5-year overall survival of RAAS is better than that of cutaneous angiosarcoma (CAS), suggesting that the prognostic factors of RAAS and CAS might be different, at least in part. In this report, we describe a case of RAAS, and employed immunohistochemical (IHC) staining of PD-L1 and MMP9 as well as periostin, IL-4, and CD163. Interestingly, IHC staining revealed that the RAAS in our case was positive for PD-L1 and negative for MMP9. Moreover, the predominant stromal factor of our case was periostin, suggesting that TAMs in the present case was not immunosuppressive, but an inflammatory subtype. These results might explain, at least in part, the better prognosis of RAAS compared to CAS. (C) 2018 The Author(s) Published by S. Karger AG, Basel

引用

页码：330 / 335

页数：6

共 14 条

[1] Treatment and prognostic factors of radiation-associated angiosarcoma (RAAS) after primary breast cancer: A systematic review [J].

Depla, A. L. ;

Scharloo-Karels, C. H. ;

de Jong, M. A. A. ;

Oldenborg, S. ;

Kolff, M. W. ;

Oei, S. B. ;

van Coevorden, F. ;

van Rhoon, G. C. ;

Baartman, E. A. ;

Scholten, R. J. ;

Crezee, J. ;

van Tienhoven, G. .

EUROPEAN JOURNAL OF CANCER, 2014, 50 (10) :1779-1788

[2] Tumor-Associated Macrophages: Therapeutic Targets for Skin Cancer [J].

Fujimura, Taku ;

Kambayashi, Yumi ;

Fujisawa, Yasuhiro ;

Hidaka, Takanori ;

Aiba, Setsuya .

FRONTIERS IN ONCOLOGY, 2018, 8

[3] Cutaneous Angiosarcoma: The Possibility of New Treatment Options especially for Patients with Large Primary Tumor [J].

Fujisawa, Yasuhiro ;

Yoshino, Koji ;

Fujimura, Taku ;

Nakamura, Yoshiyuki ;

Okiyama, Naoko ;

Ishitsuka, Yosuke ;

Watanabe, Rei ;

Fujimoto, Manabu .

FRONTIERS IN ONCOLOGY, 2018, 8

[4] The possible interaction between periostin expressed by cancer stroma and tumor-associated macrophages in developing mycosis fungoides [J].

Furudate, Sadanori ;

Fujimura, Taku ;

Kakizaki, Aya ;

Kambayashi, Yumi ;

Asano, Masayuki ;

Watabe, Akiko ;

Aiba, Setsuya .

EXPERIMENTAL DERMATOLOGY, 2016, 25 (02) :107-112

[5] Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells [J].

Getts, Daniel R. ;

Turley, Danielle M. ;

Smith, Cassandra E. ;

Harp, Christopher T. ;

McCarthy, Derrick ;

Feeney, Emma M. ;

Getts, Meghann Teague ;

Martin, Aaron J. ;

Luo, Xunrong ;

Terry, Rachael L. ;

King, Nicholas J. C. ;

Miller, Stephen D. .

JOURNAL OF IMMUNOLOGY, 2011, 187 (05) :2405-2417

[6] Infiltration of PD-1-positive cells in combination with tumor site PD-L1 expression is a positive prognostic factor in cutaneous angiosarcoma [J].

Honda, Yuki ;

Otsuka, Atsushi ;

Ono, Sachiko ;

Yamamoto, Yosuke ;

Seidel, Judith A. ;

Morita, Satoshi ;

Hirata, Masahiro ;

Kataoka, Tatsuki R. ;

Takenouchi, Tatsuya ;

Fujii, Kazuyasu ;

Kanekura, Takuro ;

Okubo, Yuko ;

Takahashi, Kenzo ;

Yanagi, Teruki ;

Hoshina, Daichi ;

Hata, Hiroo ;

Abe, Riichiro ;

Fujimura, Taku ;

Funakoshi, Takeru ;

Yoshino, Koji ;

Masuzawa, Mamiko ;

Amoh, Yasuyuki ;

Tanaka, Ryota ;

Fujisawa, Yasuhiro ;

Honda, Tetsuya ;

Kabashima, Kenji .

ONCOIMMUNOLOGY, 2017, 6 (01)

[7] Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate [J].

Ishibashi, Masaya ;

Fujimura, Taku ;

Hashimoto, Akira ;

Haga, Takahiro ;

Onami, Kaoru ;

Tsukada, Akira ;

Kambayashi, Yumi ;

Hidaka, Takanori ;

Furudate, Sadanori ;

Shimada, Ryoko ;

Aiba, Setsuya .

CASE REPORTS IN DERMATOLOGY, 2012, 4 (01) :5-9

[8] Comparison of Immunosuppressive and Cytotoxic Cells in Angiosarcoma: Development of a Possible Supportive Therapy for Angiosarcoma [J].

Kambayashi, Yumi ;

Fujimura, Taku ;

Furudate, Sadanori ;

Hashimoto, Akira ;

Haga, Takahiro ;

Aiba, Setsuya .

DERMATOLOGY, 2013, 227 (01) :14-20

[9] Radiation-Associated Angiosarcoma of the Breast: A Case Report and Literature Review [J].

Lyou, Yung ;

Barber, Emily ;

Mehta, Rita ;

Lee, Thomas ;

Goreal, Wamda ;

Parajuli, Ritesh .

CASE REPORTS IN ONCOLOGY, 2018, 11 (01) :216-220

[10] Immunohistochemical Study of the Expression of Matrix Metalloproteinase-9 in Skin Lesions of Mycosis Fungoides [J].

Rasheed, Hoda ;

Fawzi, Marwa Mohsen Tolba ;

Abdel-Halim, Mona R. E. ;

Eissa, Amal M. ;

Salem, Nahla Mohammed ;

Mahfouz, Soheir .

AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2010, 32 (02) :162-169

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