THE HEMODYNAMIC-EFFECTS OF GR-32191, A THROMBOXANE-A(2) RECEPTOR ANTAGONIST, IN PATIENTS WITH RENAL-ARTERY STENOSIS AND HYPERTENSION

被引：2
|
作者：
LYONS, D
FOWLER, G
PETRIE, JC
WEBSTER, J
机构：
[1] Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1993年 / 36卷 / 03期
关键词：
THROMBOXANE-A(2); GR-32191; HYPERTENSION; RENAL ARTERY STENOSIS; RECEPTOR ANTAGONIST;
D O I：
10.1111/j.1365-2125.1993.tb04229.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study was designed to determine if GR 32191, a thromboxane A2 receptor antagonist, would lower blood pressure in patients with hypertension and renal artery stenosis. Eight patients with unilateral atheromatous renal artery stenosis and hypertension were studied in a double-blind, single dose, placebo controlled, crossover study. The results show that, GR 32191, given orally, in doses of 20 mg and 40 mg, does not reduce the blood pressure to any clinically important degree.
引用
收藏
页码：271 / 273
页数：3
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