BIOTRANSFORMATIONS BY MICROBIAL BAEYER-VILLIGER MONOOXYGENASES STEREOSELECTIVE LACTONE FORMATION INVITRO BY COUPLED ENZYME-SYSTEMS

被引：30

作者：

GROGAN, G

ROBERTS, S

WILLETTS, A

机构：

[1] UNIV EXETER,DEPT BIOL SCI,EXETER EX4 4QG,DEVON,ENGLAND

[2] UNIV EXETER,DEPT BIOL SCI,DEPT CHEM,EXETER EX4 4QG,DEVON,ENGLAND

来源：

BIOTECHNOLOGY LETTERS | 1992年 / 14卷 / 12期

关键词：

D O I：

10.1007/BF01027014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The regio- and stereoselective biotransformation of bicyclo(3.2.0)hept-2-en-6-one by the NADH-dependent Baeyer-Villiger monooxygenase from camphor-grown Pseudomonas putida NCIMB 10007 has been shown to yield a chiral lactone not accessible by currently-used biocatalysts. The biotransformation can be conducted in vitro using two alternative coupled enzyme systems (alcohol dehydrogenase and monooxygenase: formate dehydrogenase and monooxygenase) with in situ recycling of NAD+/NADH.

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页码：1125 / 1130

页数：6

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