THE MANAGEMENT OF ISOLATED RENAL RECURRENCE OF RENAL-CELL CARCINOMA FOLLOWING COMPLETE RESPONSE TO INTERLEUKIN-2 BASED IMMUNOTHERAPY

被引：12

作者：

LONG, JP ^{[1
]}

WALTHER, MM ^{[1
]}

ALEXANDER, RB ^{[1
]}

LINEHAN, WM ^{[1
]}

ROSENBERG, SA ^{[1
]}

机构：

[1] NCI,DIV CANC TREATMENT,SURG BRANCH,BETHESDA,MD 20892

来源：

JOURNAL OF UROLOGY | 1993年 / 150卷 / 01期

关键词：

CARCINOMA; RENAL CELL; KIDNEY NEOPLASMS; NEOPLASM METASTASIS; INTERLEUKIN-2; IMMUNOTHERAPY;

D O I：

10.1016/S0022-5347(17)35428-9

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The role of interleukin-2 based immunotherapy in advanced renal cell carcinoma is gradually expanding. Among patients who achieve significant responses to these regimens the subsequent development of isolated recurrences raises difficult management questions. We report 2 unusual cases of isolated recurrence in the remaining kidney following a sustained, complete response to interleukin-2 based adoptive immunotherapy. Both patients were treated with interleukin-2 based therapy following surgical resection of the primary renal tumor. The disease course of each patient is described and the literature is reviewed. Both patients were free of disease after relatively short-term followup. Surgery for patients with limited recurrence of renal cell carcinoma following an objective response to immunotherapy may, in select cases, be a reasonable treatment alternative.

引用

页码：176 / 178

页数：3

共 23 条

[1] ACINO SM, 1988, EUR UROL, V15, P294
[2] ANGLARD P, 1991, CANCER RES, V51, P1071
[3] GOLDSTEIN D, 1986, CANCER RES, V46, P4315
[4] LOWER URINARY TRACT IMPLANTS OR METASTASES FROM CLEAR CELL CARCINOMA OF THE KIDNEY
HESLIN, JE
MILNER, WA
GARLICK, WB
[J]. JOURNAL OF UROLOGY, 1955, 73 (01) : 39 - 46
[5] JACOBS SC, 1980, CANCER, V46, P2341, DOI 10.1002/1097-0142(19801201)46:11<2341::AID-CNCR2820461103>3.0.CO
[6] 2-O
[7] KANETOH H, 1985, EUR UROL, V11, P273
[8] SECONDARY TUMORS OF THE GENITO-URINARY TRACT
KLINGER, ME
[J]. JOURNAL OF UROLOGY, 1951, 65 (01) : 144 - 153
[9] KROWN SE, 1987, CANCER, V59, P647, DOI 10.1002/1097-0142(19870201)59:3+<647::AID-CNCR2820591313>3.0.CO
[10] 2-#

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