SYNTHESIS OF PODOPHYLLUM LIGNAN ANALOGS

被引：0

作者：

MITRA, J ^{[1
]}

MITRA, AK ^{[1
]}

机构：

[1] UNIV CALCUTTA,UNIV COLL SCI,DEPT CHEM,CALCUTTA 700009,W BENGAL,INDIA

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1992年 / 31卷 / 07期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three podophyllotoxin analogues 1-3 having unsymmetrically substituted methoxyl groups in the pendant aryl ring have been synthesized by the application of tandem conjugate addition reaction. Piperonal propane-1, 3-dithiane, but-2-en-4-olide and 2, 3, 4-trimethoxybenzaldehyde furnish a lactone alcohol 5a, which upon desulphurization followed by cyclization yields 3-hydroxymethyl-6, 7-methylenedioxy-1-(2', 3', 4'-trimethoxyphenyl-1, 2, 3, 4-tetrahydro-2-naphthoic acid gamma-lactone 1. Cyclization of 5a followed by dethioketalization affords 3. The use of 2, 4, 5-trimethoxybenzaldehyde as substrate furnishes the aryltetralin lignan analogue 2.

引用

页码：452 / 455

页数：4

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