EXPERIMENTAL ALLERGIC NEURITIS INDUCED BY SENSITIZATION WITH GALACTOCEREBROSIDE

被引：183
作者：
SAIDA, T
SAIDA, K
DORFMAN, SH
SILBERBERG, DH
SUMNER, AJ
MANNING, MC
LISAK, RP
BROWN, MJ
机构：
[1] Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia
来源：
SCIENCE | 1979年 / 204卷 / 4397期
关键词：
D O I：
10.1126/science.451555
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Thirteen of 31 rabbits immunized repeatedly with bovine brain galactocerebroside developed experimental allergic neuritis, manifested by flaccid paresis and hypesthesia of four limbs, 2 to 11 months after the initial inoculation. Electrophysiological studies revealed multifocal conduction block of peripheral nerves. Perivenular demyelinative lesions associated with phagocytic mononuclear cells occurred in spinal ganglia, roots, and less frequently in distal nerves. Copyright © 1979 AAAS.
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页码：1103 / 1106
页数：4
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