LOW-DOSE METHOTREXATE COMPARED WITH AURANOFIN IN ADULT RHEUMATOID-ARTHRITIS - A 36-WEEK, DOUBLE-BLIND TRIAL

被引：133

作者：

WEINBLATT, ME

KAPLAN, H

GERMAIN, BF

MERRIMAN, RC

SOLOMON, SD

WALL, B

ANDERSON, L

BLOCK, S

IRBY, R

WOLFE, F

GALL, E

TORRETTI, D

BIUNDO, J

SMALL, R

COBLYN, J

POLISSON, R

机构：

[1] DENVER ARTHRIT CLIN,DENVER,CO

[2] UNIV S FLORIDA,COLL MED,TAMPA,FL 33612

[3] BAYLOR UNIV,MED CTR,DALLAS,TX

[4] ARTHRIT RHEUMAT & BACK DIS ASSOCIATES,CHERRY HILL,NJ

[5] COLUMBUS MED CTR,COLUMBUS,OH

[6] RHEUMATOL ASSOCIATES,PORTLAND,ME

[7] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298

[8] ARTHRIT CTR,WICHITA,KS

[9] ARIZONA HLTH SCI CTR,TUCSON,AZ 85724

[10] GEISINGER MED CTR,DANVILLE,PA 17822

[11] LOUISIANA STATE UNIV,MED CTR,NEW ORLEANS,LA 70112

[12] DUKE UNIV,MED CTR,DURHAM,NC 27710

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 03期

关键词：

D O I：

10.1002/art.1780330305

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Weekly treatment with low‐dose oral methotrexate (MTX) was compared with daily auranofin (AUR) treatment in a 36‐week double‐blind, randomized, multicenter study of 281 patients with active, adult‐onset rheumatoid arthritis. Both treatment groups showed significant improvement by the usual measures of clinical efficacy. The response with MTX occurred earlier and was consistently greater than that with AUR. An intent‐to‐treat analysis showed significantly greater improvement (P < 0.01) with MTX for painful and swollen joint counts and physician and patient global assessments of disease activity. Adverse reactions were reported more frequently in the AUR group, and more AUR‐treated patients were withdrawn from the study because of toxicity. MTX was thus more effective and better tolerated than AUR in this study. Copyright © 1990 American College of Rheumatology

引用

页码：330 / 338

页数：9

共 30 条

[1] WEEKLY PULSE METHOTREXATE IN RHEUMATOID-ARTHRITIS - CLINICAL AND IMMUNOLOGICAL EFFECTS IN A RANDOMIZED, DOUBLE-BLIND-STUDY [J].