CYTOMEGALOVIRUS CULTURES DURING MAINTENANCE DHPG THERAPY FOR CYTOMEGALOVIRUS (CMV) RETINITIS IN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)

被引：4

作者：

JENNENS, ID

LUCAS, CR

SANDLAND, AM

MACLEAN, H

HAYES, K

机构：

[1] FAIRFIELD HOSP,DEPT MED,POB 65,FAIRFIELD,VIC 3078,AUSTRALIA

[2] FAIRFIELD HOSP,DEPT VIROL,FAIRFIELD,VIC 3078,AUSTRALIA

[3] UNIV MELBOURNE,DEPT OPHTHALMOL,PARKVILLE,VIC 3052,AUSTRALIA

来源：

JOURNAL OF MEDICAL VIROLOGY | 1990年 / 30卷 / 01期

关键词：

CMV retinitis; ganciclovir; virus isolation;

D O I：

10.1002/jmv.1890300109

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nine patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus (CMV) retinitis on maintenance therapy with ganciclovir: 9(1,3‐dihydroxy‐2‐propoxymethyl) guanine (DHPG) at high dose (30 mg/kg/week) or low dose (20 mg/kg/week) were tested every 1–2 weeks for CMV isolation from blood, saliva, and urine. Duration of therapy ranged from 1.5 to 12 months (average 5.3 months). During pretreatment and low‐dose and high‐dose maintenance therapy, CMV was isolated from 48/59 (81%), 90/211 (43%), and 40/290 (14%) of specimens, respectively. Three patients with progressive retinitis had viraemia more frequently than did six patients with stable retinitis, CMV being isolated from 29/47 (62%) and 17/121 (14%) of blood samples, respectively. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：42 / 44

页数：3

共 8 条

[1]

HALLARD GN, 1986, ARCH OPTHALMOLOGY, V101, P1794

[2] SERIOUS CYTOMEGALO-VIRUS DISEASE IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) [J].