STRUCTURAL STUDIES OF VINBLASTINE ALKALOIDS BY EXCITON COUPLED CIRCULAR-DICHROISM

被引：0

作者：

DONG, JG

BORNMANN, W

NAKANISHI, K

BEROVA, N

机构：

[1] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

[2] MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021

来源：

PHYTOCHEMISTRY | 1995年 / 40卷 / 06期

关键词：

CATHARANTHUS ROSEUS; APOCYNACEAE; CIRCULAR DICHROISM; EXCITON COUPLING; ABSOLUTE CONFIGURATION; VINBLASTINE ALKALOIDS;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SCF-CI-dipole velocity MO calculations have shown that the bisignate circular dichroic curves of vinblastine/vincristine alkaloids at ca 210 and 220-230 nm are due to exciton coupling between the indoline and indole moieties. Furthermore, a combination of X-ray crystal structure data with MM2 local energy minimization provides a convenient means for estimation of the preferred solution conformation.

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页码：1821 / 1824

页数：4

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