THE GENOMIC STRUCTURE OF THE STAT GENES - MULTIPLE EXONS IN COINCIDENT SITES IN STAT1 AND STAT2

被引:57
作者
YAN, RQ [1 ]
QURESHI, S [1 ]
ZHONG, Z [1 ]
WEN, ZL [1 ]
DARNELL, JE [1 ]
机构
[1] ROCKEFELLER UNIV,MOLEC CELL BIOL LAB,NEW YORK,NY 10021
关键词
D O I
10.1093/nar/23.3.459
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The genomic structure of Stat2 has been determined and compared with a large portion of the Stat1 gene. There are 24 exons in the Stat2 gene and a matching number in very similar positions in the Stat1 gene. Thus a very complicated genomic structure was presumably duplicated and has been closely maintained throughout evolution.
引用
收藏
页码:459 / 463
页数:5
相关论文
共 27 条
[1]   HUMAN CELLULAR SRC GENE - NUCLEOTIDE-SEQUENCE AND DERIVED AMINO-ACID SEQUENCE OF THE REGION CODING FOR THE CARBOXY-TERMINAL 2-THIRDS OF PP60C-SRC [J].
ANDERSON, SK ;
GIBBS, CP ;
TANAKA, A ;
KUNG, HJ ;
FUJITA, DJ .
MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (05) :1122-1129
[2]  
BOISCLAIR YR, 1993, J BIOL CHEM, V268, P24892
[3]   JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS [J].
DARNELL, JE ;
KERR, IM ;
STARK, GR .
SCIENCE, 1994, 264 (5164) :1415-1421
[4]   SELECTION OF SPLICE SITES IN PRE-MESSENGER-RNAS WITH SHORT INTERNAL EXONS [J].
DOMINSKI, Z ;
KOLE, R .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (12) :6075-6083
[5]   THE PROTEINS OF ISGF-3, THE INTERFERON ALPHA-INDUCED TRANSCRIPTIONAL ACTIVATOR, DEFINE A GENE FAMILY INVOLVED IN SIGNAL TRANSDUCTION [J].
FU, XY ;
SCHINDLER, C ;
IMPROTA, T ;
AEBERSOLD, R ;
DARNELL, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7840-7843
[6]   A SURVEY ON INTRON AND EXON LENGTHS [J].
HAWKINS, JD .
NUCLEIC ACIDS RESEARCH, 1988, 16 (21) :9893-9908
[7]   SYNERGISTIC ACTION OF INTERLEUKIN-6 AND GLUCOCORTICOIDS IS MEDIATED BY THE INTERLEUKIN-6 RESPONSE ELEMENT OF THE RAT ALPHA(2) MACROGLOBULIN GENE [J].
HOCKE, GM ;
BARRY, D ;
FEY, GH .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (05) :2282-2294
[8]   TYROSINE PHOSPHORYLATION OF DNA-BINDING PROTEINS BY MULTIPLE CYTOKINES [J].
LARNER, AC ;
DAVID, M ;
FELDMAN, GM ;
IGARASHI, K ;
HACKETT, RH ;
WEBB, DSA ;
SWEITZER, SM ;
PETRICOIN, EF ;
FINBLOOM, DS .
SCIENCE, 1993, 261 (5129) :1730-1733
[9]   SYNERGISTIC INTERACTION BETWEEN INTERFERON-ALPHA AND INTERFERON-GAMMA THROUGH INDUCED SYNTHESIS OF ONE SUBUNIT OF THE TRANSCRIPTION FACTOR ISGF3 [J].
LEVY, DE ;
LEW, DJ ;
DECKER, T ;
KESSLER, DS ;
DARNELL, JE .
EMBO JOURNAL, 1990, 9 (04) :1105-1111
[10]   CYTOPLASMIC ACTIVATION OF ISGF3, THE POSITIVE REGULATOR OF INTERFERON-ALPHA-STIMULATED TRANSCRIPTION, RECONSTITUTED INVITRO [J].
LEVY, DE ;
KESSLER, DS ;
PINE, R ;
DARNELL, JE .
GENES & DEVELOPMENT, 1989, 3 (09) :1362-1371