SELFISH BEHAVIOR OF RESTRICTION-MODIFICATION SYSTEMS

被引：291

作者：

NAITO, T ^{[1
]}

KUSANO, K ^{[1
]}

KOBAYASHI, I ^{[1
]}

机构：

[1] UNIV TOKYO, INST MED SCI, DEPT MOLEC BIOL, TOKYO 108, JAPAN

来源：

SCIENCE | 1995年 / 267卷 / 5199期

关键词：

D O I：

10.1126/science.7846533

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plasmids carrying gene pairs encoding type II DNA restriction endonucleases and their cognate modification enzymes were shown to have increased stability in Escherichia coli. The descendants of cells that had lost these genes appeared unable to modify a sufficient number of recognition sites in their chromosomes to protect them from lethal attack by the remaining restriction enzyme molecules. The capacity of these genes to act as a selfish symbiont is likely to have contributed to the evolution of restriction-modification gene pairs.

引用

页码：897 / 899

页数：3

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