MECHANISM OF ACTION OF 1-BETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE (VIRAZOLE) - NEW BROAD-SPECTRUM ANTIVIRAL AGENT

被引：494

作者：

STREETER, DG ^{[1
]}

WITKOWSKI, JT ^{[1
]}

KHARE, GP ^{[1
]}

SIDWELL, RW ^{[1
]}

BAUER, RJ ^{[1
]}

ROBINS, RK ^{[1
]}

SIMON, LN ^{[1
]}

机构：

[1] NUCL ACID RES INST, INT CHEM & NUCL CORP, IRVINE, CA 92664 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1973年 / 70卷 / 04期

关键词：

D O I：

10.1073/pnas.70.4.1174

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：1174 / 1178

页数：5

共 23 条

[1]

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[2]

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[3] IN VITRO ANTIVIRAL ACITVITY OF MYCOPHENOLIC ACID AND ITS REVERSAL BY GUANINE-TYPE COMPOUNDS [J].

CLINE, JC ;

NELSON, JD ;

GERZON, K ;

WILLIAMS, RH ;

DELONG, DC .

APPLIED MICROBIOLOGY, 1969, 18 (01) :14-&

[4] INHIBITION OF NUCLEIC ACID SYNTHESIS BY MYCOPHENOLIC ACID [J].

FRANKLIN, TJ ;

COOK, JM .

BIOCHEMICAL JOURNAL, 1969, 113 (03) :515-+

[5] INOSINE 5'-PHOSPHATE DEHYDROGENASE . SITE OF INHIBITION BY GUANOSINE 5'-PHOSPHATE AND OF INACTIVATION BY 6-CHLORO-AND 6-MERCAPTOPURINE RIBONUCLEOSIDE K'-PHOSPHATES [J].

HAMPTON, A ;

NOMURA, A .

BIOCHEMISTRY, 1967, 6 (03) :679-&

[6]

HAMPTON A, 1963, J BIOL CHEM, V238, P3068

[7]

KANZAWA F, 1971, CHEM PHARM BULL, V19, P1737

[8] NUCLEOSIDE ANALOGUES AS CHEMOTHERAPEUTIC ANTIVIRAL AGENTS [J].

KAPLAN, AS ;

BENPORAT, T .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1970, 173 (01) :346-&

[9]

KHARE GP, 1972, 72 M AM SOC MICR, P227

[10]

KHARE GP, 1972, 5 INT C PHARM, P124

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