CYCLIC UREAS .2. RACEMATES AND ENANTIOMERS OF IMIDAZOLIDIN-2-ONES - SYNTHESES, CONFIGURATIONS AND SEDATIVE-HYPNOTIC ACTIVITY

被引：4

作者：

KNABE, J ^{[1
]}

BUCH, HP ^{[1
]}

BIWERSI, J ^{[1
]}

机构：

[1] UNIV SAARLAND,INST PHARMACOL & TOXIKOL,W-6650 HOMBURG,GERMANY

来源：

ARCHIV DER PHARMAZIE | 1993年 / 326卷 / 06期

关键词：

D O I：

10.1002/ardp.19933260605

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The racemates and the enantiomers of the imidazolidin-2-ones 2a and 2b, which can be considered as cyclic ureas, are obtained from the racemates and the enantiomers of the hydantoins la and lb by reduction with LiAlH4/AlCl3. The enantiomers that are dextrorotating in ethanol possess S-configuration. - In a study with Wistar-rats, 2a and 2b show sedative-hypnotic activity. The enantiomers exhibit marked enantioselective differences in their potency.

引用

页码：331 / 334

页数：4

共 6 条

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[4] CYCLIC UREAS .1. RACEMATES AND ENANTIOMERS OF HEXAHYDROPYRIMIDIN-2-ONES - SYNTHESES, CONFIGURATIONS AND SEDATIVE-HYPNOTIC ACTIVITY
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[J]. ARCHIV DER PHARMAZIE, 1993, 326 (02) : 79 - 84
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