EFFECT OF ETHANOL AND DSIP ON THE 36 CL-36(-) FLUX IN SYNAPTOSOMAL VESICLES

被引：2

作者：

YUKHANANOV, R ^{[1
]}

REBROV, I ^{[1
]}

TENNILA, T ^{[1
]}

MAISKY, A ^{[1
]}

机构：

[1] UNIV KUOPIO,SF-70211 KUOPIO 21,FINLAND

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1991年 / 15卷 / 03期

关键词：

DELTA-SLEEP-INDUCING PEPTIDE; MUSCIMOL STIMULATED 36CL- UPTAKE; ETHANOL; STRESS; DIAZEPAM;

D O I：

10.1007/BF03161062

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Delta-sleep-inducing peptide (DSIP) is an endogenous substance that regulates the response of the organism to stress. It was found that DSIP, like diazepam and ethanol, activates muscimol-stimulated Cl-36(-) uptake in the rat brain cortex and partially counteracts the stimulatory action of ethanol on this process. The effect of peptide disappears at the lowering of the incubation temperature. We propose that DSIP is a concordant regulator partly mediating its action through the membrane phospholipids.

引用

页码：235 / 248

页数：14

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