ASYMMETRIC-SYNTHESIS OF BETA-AMINO ACIDS AND ALPHA-DEUTERATED BETA-AMINO ACIDS VIA CONJUGATE ADDITION OF HOMOCHIRAL AMIDOCUPRATES

被引：0

作者：

SEWALD, N ^{[1
]}

HILLER, KD ^{[1
]}

HELMREICH, B ^{[1
]}

机构：

[1] TECH UNIV MUNICH,INST WASSERGUTE & ABFALLWIRTSCH,D-85747 GARCHING,GERMANY

来源：

LIEBIGS ANNALEN | 1995年 / 05期

关键词：

ASYMMETRIC CONJUGATE ADDITION; ALPHA; BETA-UNSATURATED ESTERS; HOMOCHIRAL AMIDOCUPRATES; BETA-AMINO ACIDS; ALPHA-DEUTERIO BETA-AMINO ACIDS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conjugate addition of homochiral amidocuprates based on N-[(R)-1-phenylethyl]trimethylsilylamine or bis[(R)-1-phenylethyl]amine to alpha,beta-unsaturated esters provides an efficient methodology for the asymmetric synthesis of beta-amino acids. Trapping of the intermediate enolate with D2O yields alpha-deuterated beta-amino acids with excellent stereoselectivity.

引用

页码：925 / 928

页数：4

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